COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01246-0013-0000-9
Chemical Name: 2,6-Dichloro-p-phenylenediamine
CASRN: 609-20-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 479181_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/13/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 9091 50 13 10 0 0 0 0 2 25 0.50 0.30 34.00 22.00
    9095 50 50 8 0 0 0 1 0 59 1.18 1.02 38.00 26.00
    9107 50 65 29 0 1 0 0 0 95 1.90 1.30 58.00 46.00
    9117 50 51 10 1 0 1 0 1 64 1.28 1.08 38.00 32.00
    9119 50 46 18 0 0 0 0 0 64 1.28 0.92 42.00 30.00
    9127 50 81 14 0 0 0 0 1 96 1.92 1.64 44.00 36.00
    9147 50 39 8 0 0 1 0 0 48 0.96 0.80 28.00 24.00
    9155 50 41 14 0 0 0 0 0 55 1.10 0.82 30.00 24.00
Average         48.3 13.9 0.1 0.1 0.3 0.1 0.5 63.3 1.27 0.99 39.00 30.00
± SEM                         0.17 0.14 3.34 2.83
 
Test Chemical 2,6-Dichloro-p-phenylenediamine 
100         
 9126 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9136 50 2 0 0 0 0 0 1 3 0.06 0.06 4.00 4.00
    9142 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9148 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9149 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9150 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9154 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9157 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.1 0.5 0.0 0.0 0.0 0.0 0.1 1.8 0.04 0.03 3.25 2.25
± SEM                         0.01 0.01 0.75 0.59
 
Test Chemical 2,6-Dichloro-p-phenylenediamine 
200         
 9122 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9123 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    9131 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9134 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9139 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    9144 50 10 2 0 0 0 0 0 12 0.24 0.20 6.00 2.00
    9145 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    9159 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         2.0 1.1 0.0 0.0 0.0 0.0 0.1 3.3 0.07 0.04 3.75 1.75
± SEM                         0.03 0.02 1.03 0.45
 
Test Chemical 2,6-Dichloro-p-phenylenediamine 
400         
 9125 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9128 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9132 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    9135 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    9143 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    9146 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9158 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9160 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
Average         0.9 1.3 0.0 0.0 0.0 0.0 0.3 2.4 0.05 0.02 4.00 1.75
± SEM                         0.01 0.01 0.76 0.70
 
Vehicle Control No Stressor 
 0         
 9097 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9105 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9113 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    9124 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9129 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9133 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9137 50 12 1 0 0 0 0 0 13 0.26 0.24 8.00 6.00
    9151 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.5 0.6 0.0 0.0 0.0 0.0 0.0 2.1 0.04 0.03 1.75 0.75
± SEM                         0.03 0.03 0.96 0.75
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation