Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01246-0013-0000-9 |
Chemical Name: | 2,6-Dichloro-p-phenylenediamine |
CASRN: | 609-20-1 |
NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
NTP Study ID: | 479181_CA |
Study Result: | Positive |
Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.
Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Result |
---|---|---|---|---|---|---|---|
11/17/1988 | Bone Marrow | 17 | Male | Mouse | B6C3F1 | Intraperitoneal Injection x 1/study, 17 hour | Positive |
Dose (mg/kg) |
Animal Number |
No. Cells |
Chromatid | Isochromatid | Exchanges | Aberrations | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Breaks | Gaps | Breaks | Gaps | 'Tid | 'Some | Other | Total | Per Cell | % Cells w/ Abs | |||||||
(+ Gaps) | (- Gaps) | (+ Gaps) | (- Gaps) | |||||||||||||
Positive Control | Dimethylbenzanthracene |
100 |
10534 | 50 | 13 | 9 | 0 | 1 | 0 | 0 | 0 | 23 | 0.46 | 0.26 | 30.00 | 24.00 |
10537 | 50 | 23 | 11 | 0 | 0 | 0 | 0 | 1 | 35 | 0.70 | 0.48 | 32.00 | 26.00 | |||
10552 | 50 | 18 | 4 | 0 | 1 | 0 | 0 | 2 | 25 | 0.50 | 0.40 | 22.00 | 18.00 | |||
10566 | 50 | 11 | 10 | 0 | 0 | 0 | 1 | 0 | 22 | 0.44 | 0.24 | 26.00 | 20.00 | |||
10585 | 50 | 8 | 6 | 0 | 0 | 0 | 0 | 0 | 14 | 0.28 | 0.16 | 20.00 | 12.00 | |||
10592 | 50 | 7 | 6 | 1 | 0 | 0 | 0 | 0 | 14 | 0.28 | 0.16 | 16.00 | 10.00 | |||
10600 | 50 | 10 | 10 | 0 | 0 | 0 | 0 | 0 | 20 | 0.40 | 0.20 | 28.00 | 16.00 | |||
10602 | 50 | 19 | 7 | 0 | 0 | 0 | 0 | 0 | 26 | 0.52 | 0.38 | 32.00 | 22.00 | |||
Average | 13.6 | 7.9 | 0.1 | 0.3 | 0.0 | 0.1 | 0.4 | 22.4 | 0.45 | 0.29 | 25.75 | 18.50 | ||||
± SEM | 0.05 | 0.04 | 2.09 | 1.99 | ||||||||||||
Test Chemical | 2,6-Dichloro-p-phenylenediamine |
50 |
10569 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 |
10576 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 4.00 | 2.00 | |||
10578 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
10584 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
10599 | 50 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.02 | 6.00 | 2.00 | |||
10601 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
10606 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
Average | 1.0 | 1.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.1 | 0.04 | 0.02 | 3.71 | 1.71 | ||||
± SEM | 0.01 | 0.00 | 0.52 | 0.29 | ||||||||||||
Test Chemical | 2,6-Dichloro-p-phenylenediamine |
100 |
10567 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 8.00 | 6.00 |
10570 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10583 | 50 | 12 | 9 | 0 | 0 | 0 | 0 | 0 | 21 | 0.42 | 0.24 | 32.00 | 18.00 | |||
10591 | 50 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.02 | 6.00 | 2.00 | |||
10593 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10597 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 6.00 | 4.00 | |||
10603 | 50 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.06 | 8.00 | 6.00 | |||
10604 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
Average | 2.8 | 1.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 4.6 | 0.09 | 0.06 | 8.25 | 5.00 | ||||
± SEM | 0.05 | 0.03 | 3.53 | 2.00 | ||||||||||||
Test Chemical | 2,6-Dichloro-p-phenylenediamine |
150 |
10572 | 50 | 3 | 3 | 0 | 0 | 0 | 0 | 1 | 7 | 0.14 | 0.08 | 10.00 | 6.00 |
10580 | 50 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 2 | 0.04 | 0.00 | 4.00 | 0.00 | |||
10586 | 50 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.02 | 4.00 | 2.00 | |||
10587 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2 | 0.04 | 0.02 | 2.00 | 0.00 | |||
10590 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 6.00 | 4.00 | |||
10594 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 6.00 | 4.00 | |||
10595 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10605 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 4.00 | 4.00 | |||
Average | 1.3 | 1.1 | 0.0 | 0.1 | 0.0 | 0.0 | 0.3 | 2.8 | 0.06 | 0.03 | 4.75 | 2.75 | ||||
± SEM | 0.01 | 0.01 | 0.92 | 0.75 | ||||||||||||
Vehicle Control | No Stressor |
0 |
10530 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 |
10541 | 50 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.02 | 4.00 | 2.00 | |||
10565 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10568 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10571 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10582 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10588 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
10596 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
Average | 0.4 | 0.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.9 | 0.02 | 0.01 | 1.50 | 0.75 | ||||
± SEM | 0.01 | 0.00 | 0.50 | 0.37 | ||||||||||||
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation