| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01246-0012-0000-8 |
| Chemical Name: | 2,6-Dichloro-p-phenylenediamine |
| CASRN: | 609-20-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 479181_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 12/09/1987 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
7069 | 25 | 7.19 | ± | 0.546 |
| 7073 | 25 | 7.19 | ± | 0.737 | |||
| 7082 | 25 | 6.77 | ± | 0.387 | |||
| 7111 | 25 | 7.43 | ± | 0.618 | |||
| Average | 7.14 | ± | 0.138 | ||||
| Test Chemical | 2,6-Dichloro-p-phenylenediamine |
100 |
7080 | 25 | 6.03 | ± | 0.495 |
| 7081 | 25 | 6.31 | ± | 0.546 | |||
| 7085 | 25 | 5.64 | ± | 0.447 | |||
| 7091 | 25 | 6.95 | ± | 0.693 | |||
| Average | 6.23 | ± | 0.274 | ||||
| Test Chemical | 2,6-Dichloro-p-phenylenediamine |
200 |
7075 | 25 | 8.74 | ± | 0.826 |
| 7078 | 25 | 10.55 | ± | 0.944 | |||
| 7094 | 25 | 11.51 | ± | 0.865 | |||
| Average | 10.27 | ± | 0.810 | ||||
| Test Chemical | 2,6-Dichloro-p-phenylenediamine |
400 |
7076 | 25 | 11.64 | ± | 1.000 |
| 7079 | 25 | 8.77 | ± | 0.743 | |||
| 7084 | 25 | 12.41 | ± | 0.993 | |||
| 7086 | 25 | 10.54 | ± | 0.690 | |||
| Average | 10.84 | ± | 0.789 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
7056 | 25 | 14.76 | ± | 0.995 |
| 7067 | 25 | 12.38 | ± | 0.976 | |||
| 7092 | 25 | 14.40 | ± | 0.815 | |||
| 7102 | 25 | 14.30 | ± | 0.897 | |||
| Average | 13.97 | ± | 0.535 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed