| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01246-0012-0000-8 |
| Chemical Name: | 2,6-Dichloro-p-phenylenediamine |
| CASRN: | 609-20-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 479181_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 05/10/1988 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
8510 | 25 | 5.34 | ± | 0.529 |
| 8533 | 24 | 5.95 | ± | 0.540 | |||
| 8566 | 25 | 4.54 | ± | 0.393 | |||
| 8571 | 25 | 4.20 | ± | 0.356 | |||
| Average | 4.99 | ± | 0.394 | ||||
| Test Chemical | 2,6-Dichloro-p-phenylenediamine |
50 |
8514 | 25 | 4.52 | ± | 0.499 |
| 8517 | 25 | 5.66 | ± | 0.487 | |||
| 8518 | 25 | 3.90 | ± | 0.317 | |||
| 8521 | 25 | 5.65 | ± | 0.606 | |||
| Average | 4.93 | ± | 0.435 | ||||
| Test Chemical | 2,6-Dichloro-p-phenylenediamine |
100 |
8512 | 25 | 5.08 | ± | 0.553 |
| 8516 | 25 | 5.62 | ± | 0.719 | |||
| 8520 | 25 | 4.02 | ± | 0.360 | |||
| 8522 | 25 | 4.62 | ± | 0.522 | |||
| Average | 4.84 | ± | 0.341 | ||||
| Test Chemical | 2,6-Dichloro-p-phenylenediamine |
200 |
8507 | 25 | 9.88 | ± | 0.827 |
| 8508 | 25 | 7.66 | ± | 0.787 | |||
| 8509 | 25 | 4.72 | ± | 0.441 | |||
| 8513 | 25 | 5.60 | ± | 0.535 | |||
| Average | 6.97 | ± | 1.149 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
8519 | 25 | 6.21 | ± | 0.533 |
| 8536 | 25 | 7.74 | ± | 0.683 | |||
| 8541 | 25 | 7.38 | ± | 0.575 | |||
| 8561 | 25 | 6.80 | ± | 0.521 | |||
| Average | 7.03 | ± | 0.335 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed