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Study Information
Study Attribute Value
CEBS Accession Number: 002-01934-0012-0000-2
Chemical Name: Cytembena
CASRN: 21739-91-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 483291_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/13/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 9842 50 5 1 1 0 0 0 0 7 0.14 0.12 14.00 12.00
    9843 50 2 4 0 0 0 0 0 6 0.12 0.04 14.00 6.00
    9844 50 6 1 0 0 0 0 1 8 0.16 0.14 12.00 12.00
    9845 50 11 2 1 0 0 0 1 15 0.30 0.26 26.00 22.00
    9846 50 12 7 0 0 0 0 1 20 0.40 0.26 22.00 20.00
    9847 50 6 3 0 0 0 0 0 9 0.18 0.12 18.00 12.00
    9848 50 5 1 0 0 0 0 0 6 0.12 0.10 10.00 8.00
    9849 50 2 3 2 0 0 0 0 7 0.14 0.08 10.00 8.00
Average         6.1 2.8 0.5 0.0 0.0 0.0 0.4 9.8 0.20 0.14 15.75 12.50
± SEM                         0.04 0.03 2.05 2.03
 
Test Chemical Cytembena 
50         
 9802 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9803 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9804 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9805 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    9806 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    9809 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9810 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9811 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.5 0.3 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.03 3.25 2.75
± SEM                         0.01 0.01 0.92 0.75
 
Test Chemical Cytembena 
100         
 9812 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    9814 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9815 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    9816 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9817 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    9819 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    9820 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 0.7 0.0 0.0 0.0 0.0 0.0 1.6 0.03 0.02 2.57 1.43
± SEM                         0.01 0.01 0.84 0.72
 
Test Chemical Cytembena 
200         
 9822 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9823 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9824 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9825 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9826 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9828 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9829 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9830 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.6 0.4 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.01 2.00 1.25
± SEM                         0.01 0.01 0.53 0.53
 
Vehicle Control No Stressor 
 0         
 9832 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9833 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9834 50 2 1 1 0 0 0 0 4 0.08 0.06 8.00 6.00
    9835 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9836 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9837 50 4 3 0 0 0 0 0 7 0.14 0.08 14.00 8.00
    9838 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9839 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         1.1 0.8 0.1 0.0 0.0 0.0 0.0 2.0 0.04 0.03 4.00 2.50
± SEM                         0.02 0.01 1.77 1.12
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation