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Study Information
Study Attribute Value
CEBS Accession Number: 002-01934-0012-0000-2
Chemical Name: Cytembena
CASRN: 21739-91-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 483291_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
09/24/1991 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 12325 50 7 5 0 0 0 0 0 12 0.24 0.14 20.00 10.00
    12326 50 16 1 1 0 0 0 1 19 0.38 0.36 28.00 26.00
    12327 50 13 4 0 0 0 0 0 17 0.34 0.26 24.00 18.00
    12328 50 13 2 0 0 0 0 1 16 0.32 0.28 28.00 26.00
    12330 50 12 5 0 0 0 0 1 18 0.36 0.26 26.00 20.00
    12331 50 14 5 0 0 0 0 0 19 0.38 0.28 30.00 22.00
    12332 50 10 0 0 0 0 0 0 10 0.20 0.20 16.00 16.00
Average         12.1 3.1 0.1 0.0 0.0 0.0 0.4 15.9 0.32 0.25 24.57 19.71
± SEM                         0.03 0.03 1.89 2.16
 
Test Chemical Cytembena 
25         
 12285 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12286 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12287 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    12289 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12291 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12292 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12293 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    12294 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.4 0.9 0.0 0.0 0.0 0.0 0.0 2.3 0.05 0.03 4.50 2.75
± SEM                         0.01 0.01 0.91 0.92
 
Test Chemical Cytembena 
50         
 12295 50 1 1 0 1 0 0 0 3 0.06 0.02 6.00 2.00
    12296 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12297 50 0 1 0 1 0 0 0 2 0.04 0.00 2.00 0.00
    12298 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    12300 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12301 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12302 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    12304 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.1 1.0 0.0 0.3 0.0 0.0 0.0 2.4 0.05 0.02 4.50 2.25
± SEM                         0.01 0.01 1.40 1.28
 
Test Chemical Cytembena 
100         
 12305 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12306 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12307 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12308 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12309 50 8 1 1 0 0 0 0 10 0.20 0.18 16.00 14.00
    12310 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12311 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    12312 50 5 0 0 0 0 0 0 5 0.10 0.10 10.00 10.00
Average         2.1 0.5 0.1 0.0 0.0 0.0 0.0 2.8 0.06 0.05 5.00 4.00
± SEM                         0.02 0.02 1.96 1.85
 
Vehicle Control No Stressor 
 0         
 12315 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12316 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12317 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    12318 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12319 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12320 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12322 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.6 0.7 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.01 2.57 1.14
± SEM                         0.01 0.00 0.72 0.40
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation