| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01934-0011-0000-1 |
| Chemical Name: | Cytembena |
| CASRN: | 21739-91-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 483291_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 01/22/1991 | Bone Marrow | 24 | Male | Mouse | B6C3F1 | subcutaneously implanted x 1, 24 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
11585 | 25 | 2.32 | ± | 0.340 |
| 11586 | 25 | 2.89 | ± | 0.362 | |||
| 11587 | 25 | 3.92 | ± | 0.588 | |||
| 11588 | 25 | 2.53 | ± | 0.278 | |||
| Average | 2.92 | ± | 0.355 | ||||
| Test Chemical | Cytembena |
25 |
11555 | 25 | 2.28 | ± | 0.263 |
| 11556 | 25 | 4.17 | ± | 0.383 | |||
| 11557 | 25 | 3.89 | ± | 0.452 | |||
| Average | 3.44 | ± | 0.586 | ||||
| Test Chemical | Cytembena |
50 |
11562 | 25 | 4.57 | ± | 0.954 |
| 11563 | 25 | 2.64 | ± | 0.341 | |||
| 11564 | 25 | 2.56 | ± | 0.306 | |||
| 9802 | 25 | 3.05 | ± | 0.280 | |||
| Average | 3.20 | ± | 0.467 | ||||
| Test Chemical | Cytembena |
100 |
11565 | 25 | 2.48 | ± | 0.312 |
| 11566 | 25 | 3.13 | ± | 0.316 | |||
| 11567 | 25 | 3.64 | ± | 0.294 | |||
| 11568 | 25 | 4.45 | ± | 0.440 | |||
| Average | 3.43 | ± | 0.415 | ||||
| Positive Control | Mitomycin-C |
0.5 |
11590 | 25 | 5.56 | ± | 0.542 |
| 11591 | 25 | 5.53 | ± | 0.477 | |||
| 11592 | 25 | 6.96 | ± | 0.492 | |||
| 11593 | 25 | 6.48 | ± | 0.444 | |||
| Average | 6.14 | ± | 0.353 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed