| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01311-0013-0000-2 |
| Chemical Name: | 2-Chloroethanol (ethylene chlorohydrin) |
| CASRN: | 107-07-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 495716_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 02/13/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
3351 | 25 | 5.22 | ± | 0.516 |
| 3353 | 25 | 6.65 | ± | 0.503 | |||
| 3354 | 25 | 4.88 | ± | 0.518 | |||
| 3355 | 25 | 4.98 | ± | 0.487 | |||
| Average | 5.43 | ± | 0.412 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
18.75 |
3336 | 25 | 3.40 | ± | 0.408 |
| 3337 | 25 | 4.02 | ± | 0.383 | |||
| 3338 | 25 | 3.88 | ± | 0.357 | |||
| 3339 | 25 | 3.37 | ± | 0.351 | |||
| Average | 3.67 | ± | 0.166 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
37.5 |
3341 | 25 | 3.63 | ± | 0.294 |
| 3342 | 25 | 3.14 | ± | 0.324 | |||
| 3343 | 25 | 4.44 | ± | 0.471 | |||
| 3344 | 25 | 3.15 | ± | 0.381 | |||
| Average | 3.59 | ± | 0.306 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
75 |
3346 | 25 | 5.55 | ± | 0.617 |
| 3347 | 25 | 4.38 | ± | 0.468 | |||
| 3348 | 25 | 5.52 | ± | 0.483 | |||
| 3349 | 25 | 5.45 | ± | 0.420 | |||
| Average | 5.23 | ± | 0.283 | ||||
| Positive Control | Mitomycin-C |
0.5 |
3356 | 25 | 9.34 | ± | 0.799 |
| 3357 | 25 | 9.81 | ± | 0.947 | |||
| 3358 | 25 | 10.04 | ± | 0.742 | |||
| 3359 | 25 | 7.12 | ± | 0.473 | |||
| Average | 9.08 | ± | 0.669 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed