| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01311-0013-0000-2 |
| Chemical Name: | 2-Chloroethanol (ethylene chlorohydrin) |
| CASRN: | 107-07-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 495716_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 05/27/1987 | Bone Marrow | 36 | Male | Mouse | B6C3F1 | IP/IJ x 1, 36 hour | Not a Valid Test |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
5762 | 25 | 4.44 | ± | 0.484 |
| 5763 | 25 | 3.09 | ± | 0.369 | |||
| 5764 | 25 | 4.69 | ± | 0.460 | |||
| Average | 4.07 | ± | 0.498 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
18.75 |
5701 | 25 | 3.81 | ± | 0.407 |
| 5703 | 25 | 4.41 | ± | 0.367 | |||
| 5704 | 25 | 5.50 | ± | 0.496 | |||
| 5705 | 25 | 4.30 | ± | 0.495 | |||
| Average | 4.51 | ± | 0.358 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
37.5 |
5711 | 25 | 4.05 | ± | 0.507 |
| 5712 | 25 | 4.24 | ± | 0.452 | |||
| 5713 | 25 | 4.12 | ± | 0.501 | |||
| 5714 | 25 | 4.50 | ± | 0.444 | |||
| Average | 4.23 | ± | 0.100 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
75 |
5723 | 25 | 3.34 | ± | 0.607 |
| 5725 | 25 | 4.34 | ± | 0.445 | |||
| 5727 | 25 | 3.65 | ± | 0.447 | |||
| Average | 3.78 | ± | 0.294 | ||||
| Positive Control | Mitomycin-C |
1 |
5771 | 25 | 4.85 | ± | 0.498 |
| 5772 | 25 | 3.89 | ± | 0.564 | |||
| 5773 | 25 | 3.25 | ± | 0.323 | |||
| 5774 | 25 | 4.27 | ± | 0.344 | |||
| Average | 4.07 | ± | 0.335 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed