| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01311-0013-0000-2 |
| Chemical Name: | 2-Chloroethanol (ethylene chlorohydrin) |
| CASRN: | 107-07-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 495716_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 02/16/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
7385 | 25 | 2.49 | ± | 0.436 |
| 7386 | 25 | 2.52 | ± | 0.425 | |||
| 7387 | 25 | 4.22 | ± | 0.466 | |||
| 7388 | 25 | 4.50 | ± | 0.681 | |||
| Average | 3.42 | ± | 0.539 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
18.8 |
7370 | 25 | 2.53 | ± | 0.329 |
| 7371 | 25 | 3.25 | ± | 0.477 | |||
| 7372 | 25 | 3.12 | ± | 0.318 | |||
| 7373 | 25 | 3.56 | ± | 0.351 | |||
| Average | 3.12 | ± | 0.216 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
37.5 |
7375 | 25 | 3.16 | ± | 0.373 |
| 7376 | 25 | 1.96 | ± | 0.385 | |||
| 7377 | 25 | 6.17 | ± | 0.463 | |||
| 7378 | 25 | 5.89 | ± | 0.632 | |||
| Average | 4.29 | ± | 1.032 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
75 |
7380 | 25 | 7.33 | ± | 0.588 |
| 7381 | 25 | 4.70 | ± | 0.862 | |||
| 7382 | 25 | 13.55 | ± | 1.669 | |||
| 7383 | 25 | 4.29 | ± | 0.454 | |||
| Average | 7.46 | ± | 2.137 | ||||
| Positive Control | Mitomycin-C |
0.5 |
7390 | 25 | 8.04 | ± | 0.846 |
| 7391 | 25 | 8.57 | ± | 0.814 | |||
| 7392 | 25 | 6.47 | ± | 0.670 | |||
| 7394 | 25 | 11.07 | ± | 0.829 | |||
| Average | 8.54 | ± | 0.955 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed