| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01311-0013-0000-2 |
| Chemical Name: | 2-Chloroethanol (ethylene chlorohydrin) |
| CASRN: | 107-07-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 495716_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 01/03/1990 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
10635 | 25 | 2.96 | ± | 0.393 |
| 10636 | 25 | 3.08 | ± | 0.310 | |||
| 10637 | 25 | 3.24 | ± | 0.393 | |||
| 10638 | 25 | 4.18 | ± | 0.557 | |||
| Average | 3.37 | ± | 0.277 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
18.75 |
10620 | 25 | 3.80 | ± | 0.408 |
| 10621 | 25 | 2.56 | ± | 0.271 | |||
| 10623 | 25 | 3.53 | ± | 0.360 | |||
| 10624 | 25 | 3.51 | ± | 0.337 | |||
| Average | 3.35 | ± | 0.272 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
37.5 |
10625 | 25 | 2.92 | ± | 0.360 |
| 10626 | 25 | 3.36 | ± | 0.360 | |||
| 10627 | 25 | 3.16 | ± | 0.446 | |||
| 10629 | 25 | 3.04 | ± | 0.381 | |||
| Average | 3.12 | ± | 0.095 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
75 |
10630 | 25 | 3.52 | ± | 0.342 |
| 10631 | 25 | 3.60 | ± | 0.392 | |||
| 10633 | 25 | 2.69 | ± | 0.416 | |||
| 10634 | 25 | 2.96 | ± | 0.323 | |||
| Average | 3.19 | ± | 0.219 | ||||
| Positive Control | Mitomycin-C |
0.5 |
10640 | 25 | 8.68 | ± | 0.680 |
| 10641 | 25 | 8.70 | ± | 0.646 | |||
| 10642 | 25 | 7.10 | ± | 0.626 | |||
| 10643 | 25 | 11.92 | ± | 0.728 | |||
| Average | 9.10 | ± | 1.013 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed