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Study Information
Study Attribute Value
CEBS Accession Number: 002-01013-0009-0000-6
Chemical Name: 1,1,1,2-Tetrachloroethane
CASRN: 630-20-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 499400_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
10/20/1987 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 6785 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    6786 50 13 2 0 0 0 0 0 15 0.30 0.26 22.00 18.00
    6787 50 15 3 0 0 0 0 0 18 0.36 0.30 24.00 22.00
    6788 50 9 4 0 0 0 0 0 13 0.26 0.18 20.00 18.00
    6789 50 13 5 0 0 0 0 0 18 0.36 0.26 24.00 16.00
    6790 50 10 3 1 0 0 0 0 14 0.28 0.22 22.00 18.00
    6791 50 11 1 0 0 0 0 0 12 0.24 0.22 18.00 18.00
    6792 50 8 3 0 0 0 0 0 11 0.22 0.16 20.00 14.00
Average         10.3 2.6 0.1 0.0 0.0 0.0 0.0 13.0 0.26 0.21 19.50 16.25
± SEM                         0.03 0.03 2.06 1.67
 
Test Chemical 1,1,1,2-Tetrachloroethane 
300         
 6715 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6716 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6717 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    6718 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    6719 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6720 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    6721 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    6722 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
Average         1.8 0.6 0.0 0.0 0.0 0.0 0.0 2.4 0.05 0.04 4.75 3.50
± SEM                         0.01 0.01 1.06 0.91
 
Test Chemical 1,1,1,2-Tetrachloroethane 
600         
 6725 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6726 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6727 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6728 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6729 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    6730 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6731 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6732 50 6 2 0 0 0 0 0 8 0.16 0.12 14.00 12.00
Average         1.5 0.5 0.0 0.0 0.0 0.0 0.0 2.0 0.04 0.03 3.75 3.00
± SEM                         0.02 0.01 1.58 1.36
 
Test Chemical 1,1,1,2-Tetrachloroethane 
1200         
 6735 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 2.00
    6736 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    6737 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    6738 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    6739 50 7 2 0 0 0 0 0 9 0.18 0.14 18.00 14.00
    6740 50 7 0 0 0 0 0 0 7 0.14 0.14 14.00 14.00
    6741 50 6 1 0 0 0 0 0 7 0.14 0.12 14.00 12.00
    6742 50 4 2 0 0 0 0 0 6 0.12 0.08 12.00 8.00
Average         4.3 1.1 0.0 0.0 0.0 0.0 0.0 5.4 0.11 0.09 10.50 8.25
± SEM                         0.02 0.02 1.68 1.67
 
Vehicle Control No Stressor 
 0         
 6775 50 5 1 0 0 0 0 0 6 0.12 0.10 12.00 10.00
    6776 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6778 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    6779 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6780 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    6781 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6783 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6784 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
Average         1.6 0.8 0.0 0.0 0.0 0.0 0.0 2.4 0.05 0.03 4.75 3.25
± SEM                         0.01 0.01 1.31 1.06
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation