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Study Information
Study Attribute Value
CEBS Accession Number: 002-01013-0009-0000-6
Chemical Name: 1,1,1,2-Tetrachloroethane
CASRN: 630-20-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 499400_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/18/1988 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 8358 50 21 25 0 0 0 0 0 46 0.92 0.42 42.00 26.00
    8359 50 9 6 0 0 0 0 0 15 0.30 0.18 20.00 10.00
    8360 50 14 12 0 0 0 0 0 26 0.52 0.28 28.00 20.00
    8361 50 7 4 1 0 0 0 0 12 0.24 0.16 20.00 14.00
    8362 50 22 30 0 1 0 0 0 53 1.06 0.44 44.00 30.00
    8363 50 1 10 0 0 0 0 0 11 0.22 0.02 14.00 2.00
    8364 50 22 18 0 0 0 0 0 40 0.80 0.44 46.00 34.00
    8365 50 12 9 0 2 0 0 0 23 0.46 0.24 28.00 20.00
Average         13.5 14.3 0.1 0.4 0.0 0.0 0.0 28.3 0.57 0.27 30.25 19.50
± SEM                         0.11 0.05 4.35 3.76
 
Test Chemical 1,1,1,2-Tetrachloroethane 
900         
 8328 50 4 0 2 0 0 0 0 6 0.12 0.12 12.00 12.00
    8329 50 1 4 0 0 0 0 0 5 0.10 0.02 6.00 2.00
    8330 50 2 5 0 0 0 0 0 7 0.14 0.04 8.00 2.00
    8331 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    8332 50 2 4 0 0 0 0 0 6 0.12 0.04 10.00 4.00
    8333 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    8335 50 5 4 0 0 0 0 0 9 0.18 0.10 18.00 10.00
    8336 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         2.1 2.6 0.3 0.0 0.0 0.0 0.0 5.0 0.10 0.05 8.50 4.50
± SEM                         0.02 0.01 1.76 1.45
 
Test Chemical 1,1,1,2-Tetrachloroethane 
1200         
 8338 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    8339 50 3 4 0 0 0 0 0 7 0.14 0.06 8.00 4.00
    8340 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8341 50 3 2 0 0 0 0 0 5 0.10 0.06 4.00 4.00
    8342 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    8343 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8344 50 1 3 0 0 0 0 1 5 0.10 0.04 8.00 4.00
    8345 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
Average         1.4 2.0 0.0 0.0 0.0 0.0 0.1 3.5 0.07 0.03 5.00 2.50
± SEM                         0.02 0.01 1.07 0.63
 
Vehicle Control No Stressor 
 0         
 8348 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    8349 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8350 50 1 4 0 0 0 0 0 5 0.10 0.02 8.00 2.00
    8351 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    8352 50 5 5 0 0 0 0 0 10 0.20 0.10 14.00 8.00
    8353 50 11 6 0 0 0 0 0 17 0.34 0.22 18.00 14.00
    8354 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 6.00
    8355 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         3.3 2.0 0.0 0.0 0.0 0.0 0.0 5.3 0.11 0.07 7.25 5.00
± SEM                         0.04 0.03 2.23 1.65
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation