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Study Information
Study Attribute Value
CEBS Accession Number: 002-01013-0009-0000-6
Chemical Name: 1,1,1,2-Tetrachloroethane
CASRN: 630-20-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 499400_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/28/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 10420 50 7 4 0 0 0 0 0 11 0.22 0.14 14.00 8.00
    10421 50 15 2 0 0 0 0 0 17 0.34 0.30 24.00 22.00
    10422 50 5 3 0 0 0 0 0 8 0.16 0.10 14.00 10.00
    10423 50 7 5 0 1 0 0 0 13 0.26 0.14 18.00 12.00
    10424 50 5 3 0 0 0 0 0 8 0.16 0.10 16.00 10.00
    10425 50 7 3 1 0 0 0 0 11 0.22 0.16 14.00 12.00
    10426 50 8 3 0 0 0 0 0 11 0.22 0.16 14.00 12.00
    10427 50 4 2 0 0 0 0 0 6 0.12 0.08 8.00 6.00
Average         7.3 3.1 0.1 0.1 0.0 0.0 0.0 10.6 0.21 0.15 15.25 11.50
± SEM                         0.02 0.02 1.60 1.68
 
Test Chemical 1,1,1,2-Tetrachloroethane 
300         
 10380 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10381 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10382 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10383 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10384 50 0 1 0 0 0 0 0 1 0.02 0.00 0.00 0.00
    10385 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10386 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10387 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.5 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.01 2.00 1.25
± SEM                         0.01 0.01 0.76 0.65
 
Test Chemical 1,1,1,2-Tetrachloroethane 
600         
 10390 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10391 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    10392 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    10393 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10394 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10395 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10396 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10397 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.0 0.1 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.02 2.25 2.00
± SEM                         0.01 0.01 0.96 0.93
 
Test Chemical 1,1,1,2-Tetrachloroethane 
1200         
 10400 50 2 2 1 0 0 0 0 5 0.10 0.06 2.00 2.00
    10401 50 6 0 0 0 0 0 0 6 0.12 0.12 10.00 10.00
    10402 50 11 4 0 0 0 0 0 15 0.30 0.22 18.00 16.00
    10403 50 3 3 0 0 0 0 0 6 0.12 0.06 12.00 6.00
    10404 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    10405 50 5 0 0 0 0 0 0 5 0.10 0.10 10.00 10.00
    10406 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10409 50 12 2 0 0 0 0 0 14 0.28 0.24 24.00 20.00
Average         5.3 1.8 0.1 0.0 0.0 0.0 0.0 7.1 0.14 0.11 11.00 8.75
± SEM                         0.03 0.03 2.51 2.33
 
Vehicle Control No Stressor 
 0         
 10329 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10330 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10331 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10332 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10334 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10335 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10336 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10337 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.01 0.01 1.25 1.25
± SEM                         0.00 0.00 0.37 0.37
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation