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Study Information
Study Attribute Value
CEBS Accession Number: 002-03050-0016-0000-7
Chemical Name: bis(2-Chloro-1-methylethyl) ether
CASRN: 108-60-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 500655_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/19/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 10882 50 7 14 0 1 0 0 0 22 0.44 0.14 26.00 8.00
    10893 50 10 9 0 0 0 0 0 19 0.38 0.20 28.00 16.00
    10910 50 0 0 0 0 0 0 0 0 0.00 0.00 30.00 18.00
    10923 50 12 9 1 0 0 0 0 22 0.44 0.26 26.00 16.00
    10938 50 7 10 1 0 0 0 0 18 0.36 0.16 26.00 14.00
    10942 50 11 10 0 0 0 0 0 21 0.42 0.22 26.00 18.00
    10943 50 17 22 0 3 0 0 0 42 0.84 0.34 38.00 24.00
    10954 50 12 8 0 0 0 0 1 21 0.42 0.26 22.00 14.00
Average         9.5 10.3 0.3 0.5 0.0 0.0 0.1 20.6 0.41 0.20 27.75 16.00
± SEM                         0.08 0.04 1.67 1.60
 
Test Chemical bis(2-Chloro-1-methylethyl) ether 
37.5       
 10928 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10939 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10941 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10944 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    10948 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10949 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10951 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    10962 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.1 0.8 0.0 0.0 0.0 0.0 0.0 1.9 0.04 0.02 3.25 2.25
± SEM                         0.01 0.01 0.84 0.59
 
Test Chemical bis(2-Chloro-1-methylethyl) ether 
75         
 10926 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10927 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10929 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10933 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10936 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10947 50 1 2 0 0 0 0 3 6 0.12 0.08 6.00 2.00
    10958 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10965 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.5 0.0 0.0 0.0 0.0 0.4 1.4 0.03 0.02 2.00 1.00
± SEM                         0.01 0.01 0.76 0.38
 
Test Chemical bis(2-Chloro-1-methylethyl) ether 
150         
 10931 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10934 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    10935 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10945 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10952 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10956 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10957 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    10964 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.9 0.8 0.0 0.0 0.0 0.0 0.0 1.6 0.03 0.02 3.25 1.75
± SEM                         0.01 0.01 0.75 0.70
 
Vehicle Control No Stressor 
 0         
 10887 50 3 3 0 0 0 0 0 6 0.12 0.06 8.00 4.00
    10901 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10908 4 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10925 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10930 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10946 50 1 0 1 0 0 0 0 2 0.04 0.04 2.00 2.00
    10950 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10961 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 0.6 0.1 0.0 0.0 0.0 0.0 1.5 0.03 0.02 2.57 1.43
± SEM                         0.01 0.01 0.98 0.67
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation