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Study Information
Study Attribute Value
CEBS Accession Number: 002-03050-0016-0000-7
Chemical Name: bis(2-Chloro-1-methylethyl) ether
CASRN: 108-60-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 500655_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/08/1989 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 11296 50 41 14 0 0 0 0 0 55 1.10 0.82 32.00 24.00
    11314 50 21 6 0 0 0 0 1 28 0.56 0.44 14.00 6.00
    11323 50 61 7 0 0 0 0 1 69 1.38 1.24 32.00 22.00
    11335 50 40 5 0 0 0 0 0 45 0.90 0.80 26.00 20.00
    11338 50 35 7 0 0 0 0 0 42 0.84 0.70 30.00 16.00
    11355 50 5 8 0 0 0 0 0 13 0.26 0.10 20.00 8.00
    11384 50 4 10 0 2 0 0 1 17 0.34 0.10 30.00 10.00
    11387 50 51 4 0 0 0 0 0 55 1.10 1.02 24.00 18.00
Average         32.3 7.6 0.0 0.3 0.0 0.0 0.4 40.5 0.81 0.65 26.00 15.50
± SEM                         0.14 0.15 2.27 2.38
 
Test Chemical bis(2-Chloro-1-methylethyl) ether 
37.5       
 11299 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    11300 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    11301 50 0 4 0 0 0 0 0 4 0.08 0.00 6.00 0.00
    11306 50 4 2 0 0 0 0 0 6 0.12 0.08 12.00 8.00
    11313 50 2 4 0 0 0 0 0 6 0.12 0.04 10.00 4.00
    11322 50 1 7 1 1 0 0 0 10 0.20 0.04 14.00 2.00
    11326 50 0 3 0 0 0 0 0 3 0.06 0.00 2.00 0.00
    11328 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.3 3.4 0.1 0.1 0.0 0.0 0.0 4.9 0.10 0.03 7.75 2.50
± SEM                         0.02 0.01 1.44 0.98
 
Test Chemical bis(2-Chloro-1-methylethyl) ether 
75         
 11302 50 3 1 0 0 0 0 1 5 0.10 0.08 6.00 4.00
    11303 50 1 2 0 0 0 0 1 4 0.08 0.04 6.00 2.00
    11305 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11310 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11311 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    11317 50 1 4 0 0 0 0 0 5 0.10 0.02 8.00 2.00
    11325 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11330 50 1 2 0 2 0 0 1 6 0.12 0.04 6.00 4.00
Average         1.3 2.0 0.0 0.3 0.0 0.0 0.5 4.0 0.08 0.04 6.00 2.50
± SEM                         0.01 0.01 0.38 0.33
 
Test Chemical bis(2-Chloro-1-methylethyl) ether 
150         
 11304 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11307 50 0 2 0 0 0 0 1 3 0.06 0.02 6.00 2.00
    11312 50 4 3 0 0 0 0 0 7 0.14 0.08 14.00 8.00
    11315 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11319 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11320 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    11327 50 2 4 0 0 0 0 0 6 0.12 0.04 12.00 4.00
    11329 50 1 4 0 0 0 0 0 5 0.10 0.02 6.00 2.00
Average         1.5 1.9 0.0 0.0 0.0 0.0 0.1 3.5 0.07 0.03 6.50 3.25
± SEM                         0.02 0.01 1.64 0.92
 
Vehicle Control No Stressor 
 0         
 11297 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11340 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    11351 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11362 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11364 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11367 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11388 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11403 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.8 1.3 0.0 0.0 0.0 0.0 0.0 2.0 0.04 0.02 4.00 1.50
± SEM                         0.01 0.01 0.65 0.50
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation