COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-03050-0015-0000-6
Chemical Name: bis(2-Chloro-1-methylethyl) ether
CASRN: 108-60-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 500655_SCE
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.


Detailed Sister Chromatid Exchange Data (Trial 1)
Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Trial Result
09/12/1988 Bone Marrow 42 Male Mouse B6C3F1 IP/IJ x 1,  42 hour Negative

Test Group Dose
(mg/kg)		 Animal
Number		 No.
Cells		 SCE / Cell
Mean ± SEM
Vehicle Control Corn Oil 
 0         
 9921 24 3.75 ± 0.494
    9924 22 4.43 ± 0.506
    9925 23 4.92 ± 0.547
    9942 24 3.86 ± 0.560
Average   4.23 ± 0.271
 
Test Chemical bis(2-Chloro-1-methylethyl) ether 
37.5       
 9929 25 5.69 ± 0.508
    9930 25 4.59 ± 0.302
    9931 25 4.32 ± 0.481
    9937 25 7.03 ± 0.841
Average   5.41 ± 0.617
 
Test Chemical bis(2-Chloro-1-methylethyl) ether 
75         
 9918 25 5.35 ± 0.472
    9920 24 4.22 ± 0.433
    9926 24 3.73 ± 0.387
    9927 25 4.29 ± 0.494
Average   4.41 ± 0.342
 
Test Chemical bis(2-Chloro-1-methylethyl) ether 
150         
 9919 24 4.91 ± 0.451
    9922 24 3.31 ± 0.327
    9933 20 4.35 ± 0.573
    9936 25 5.01 ± 0.447
Average   4.40 ± 0.388
 
Positive Control Dimethylbenzanthracene 
2.5       
 9923 25 12.38 ± 1.059
    9928 25 12.84 ± 1.429
    9932 25 12.24 ± 1.004
    9943 25 11.05 ± 0.961
Average   12.14 ± 0.381
 

Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed