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Study Information
Study Attribute Value
CEBS Accession Number: 002-03050-0015-0000-6
Chemical Name: bis(2-Chloro-1-methylethyl) ether
CASRN: 108-60-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 500655_SCE
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.


Detailed Sister Chromatid Exchange Data (Trial 2)
Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Trial Result
02/15/1989 Bone Marrow 23 Male Mouse B6C3F1 IP/IJ x 1,  23 hour Negative

Test Group Dose
(mg/kg)		 Animal
Number		 No.
Cells		 SCE / Cell
Mean ± SEM
Vehicle Control Corn Oil 
 0         
 11161 25 5.45 ± 0.344
    11168 25 3.82 ± 0.300
    11180 25 3.86 ± 0.378
    11195 25 4.26 ± 0.373
Average   4.35 ± 0.381
 
Test Chemical bis(2-Chloro-1-methylethyl) ether 
37.5       
 11181 25 8.87 ± 0.868
    11185 24 5.16 ± 0.414
    11188 25 4.54 ± 0.408
    11190 25 5.30 ± 0.413
Average   5.98 ± 0.983
 
Test Chemical bis(2-Chloro-1-methylethyl) ether 
75         
 11173 24 4.81 ± 0.437
    11174 25 4.46 ± 0.300
    11183 25 4.63 ± 0.450
    11189 25 3.88 ± 0.396
Average   4.44 ± 0.201
 
Test Chemical bis(2-Chloro-1-methylethyl) ether 
150         
 11182 25 4.43 ± 0.360
    11184 25 4.44 ± 0.403
    11186 25 5.33 ± 0.611
    11187 25 3.93 ± 0.281
Average   4.53 ± 0.293
 
Positive Control Dimethylbenzanthracene 
2.5       
 11160 25 8.75 ± 0.803
    11172 25 7.41 ± 0.643
    11178 25 8.07 ± 0.813
    11201 25 8.59 ± 0.605
Average   8.21 ± 0.303
 

Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed