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Study Information
Study Attribute Value
CEBS Accession Number: 002-01568-0009-0000-1
Chemical Name: 8-Methoxypsoralen
CASRN: 298-81-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 501444_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/29/1991 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 253010 50 0 1 0 0 0 0 1 2 0.04 0.02 4.00 2.00
    253050 50 1 7 0 0 0 0 0 8 0.16 0.02 16.00 2.00
    253141 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    253152 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253158 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253170 50 5 4 0 0 0 0 0 9 0.18 0.10 18.00 10.00
    253177 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    253180 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    253186 50 10 4 0 0 0 0 0 14 0.28 0.20 30.00 18.00
    253188 50 4 1 1 0 0 0 0 6 0.12 0.10 12.00 10.00
Average         2.8 2.6 0.1 0.0 0.0 0.0 0.1 5.6 0.11 0.06 11.50 5.75
± SEM                         0.03 0.02 3.42 2.25
 
Test Chemical 8-Methoxypsoralen 
50         
 253147 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253148 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    253154 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253161 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    253162 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253163 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253164 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253171 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253172 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    253191 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.4 0.0 0.0 0.0 0.0 0.0 0.9 0.02 0.01 1.75 1.00
± SEM                         0.01 0.01 1.22 0.76
 
Test Chemical 8-Methoxypsoralen 
100         
 253146 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    253149 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253150 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253151 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253156 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    253165 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253173 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    253179 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253182 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253185 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.5 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.50 0.50
± SEM                         0.01 0.00 0.98 0.33
 
Test Chemical 8-Methoxypsoralen 
200         
 253100 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253142 50 2 1 0 0 0 0 1 4 0.08 0.06 6.00 4.00
    253155 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253159 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    253166 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253174 50 0 1 0 1 0 0 0 2 0.04 0.00 4.00 2.00
    253176 50 5 1 0 0 0 0 0 6 0.12 0.10 12.00 10.00
    253178 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253181 50 7 6 0 0 0 0 0 13 0.26 0.14 26.00 12.00
    253184 50 4 1 4 3 0 0 2 14 0.28 0.20 20.00 10.00
    253187 50 14 6 0 9 0 0 0 29 0.58 0.28 34.00 26.00
    253190 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         4.0 2.3 0.5 1.6 0.0 0.0 0.4 8.8 0.18 0.10 13.25 8.00
± SEM                        
 
Vehicle Control No Stressor 
 0         
 253081 50 0 1 0 0 0 0 0 1 0.02 0.00 0.00 0.00
    253145 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253153 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    253157 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253167 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253169 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    253175 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253183 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253189 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    253192 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.6 0.01 0.00 1.00 0.25
± SEM                         0.01 0.00 0.53 0.25
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation