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Study Information
Study Attribute Value
CEBS Accession Number: 002-01568-0009-0000-1
Chemical Name: 8-Methoxypsoralen
CASRN: 298-81-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 501444_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/30/1991 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 266134 50 4 4 0 0 0 0 1 9 0.18 0.10 14.00 10.00
    266144 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    266153 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266157 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266164 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    266165 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266170 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    266188 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    266199 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266209 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.0 0.9 0.0 0.0 0.0 0.0 0.1 2.0 0.04 0.02 3.50 2.25
± SEM                         0.02 0.01 1.64 1.22
 
Test Chemical 8-Methoxypsoralen 
50         
 266141 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    266156 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266166 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    266173 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266176 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266177 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266179 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    266185 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    266197 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266203 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.01 0.01 0.89 0.89
± SEM                         0.00 0.00 0.38 0.38
 
Test Chemical 8-Methoxypsoralen 
100         
 266131 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    266137 50 5 2 0 0 0 0 0 7 0.14 0.10 16.00 12.00
    266140 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266152 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266154 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266175 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266189 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    266200 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266202 50 3 4 0 0 0 0 0 7 0.14 0.06 16.00 8.00
    266204 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.1 0.9 0.0 0.0 0.0 0.0 0.0 2.0 0.04 0.02 4.50 2.75
± SEM                        
 
Test Chemical 8-Methoxypsoralen 
200         
 266136 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266142 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266151 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266158 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266160 11 0 0 0 0 0 0 0 0 0.00 0.00 9.09 9.09
    266168 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266172 26 1 0 0 0 0 0 1 2 0.08 0.08 7.69 7.69
    266178 23 1 0 0 0 0 0 0 1 0.04 0.04 4.35 4.35
    266181 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266196 22 3 0 0 0 0 0 0 3 0.14 0.14 13.64 13.64
Average         0.8 0.0 0.0 0.0 0.0 0.0 0.3 0.8 0.03 0.03 9.09 9.09
± SEM                        
 
Vehicle Control No Stressor 
 0         
 266132 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266133 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266139 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266149 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266150 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266159 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    266174 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266180 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266182 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    266191 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.01 0.00 0.50 0.25
± SEM                         0.00 0.00 0.33 0.25
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation