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Study Information
Study Attribute Value
CEBS Accession Number: 002-02466-0006-0000-6
Chemical Name: Methylenedianiline
CASRN: 101-77-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 535562_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/29/1986 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 3170 50 20 3 0 0 0 0 0 23 0.46 0.40 22.00 18.00
    3171 50 11 4 0 0 0 0 1 16 0.32 0.24 22.00 18.00
    3172 50 5 4 0 0 0 0 0 9 0.18 0.10 14.00 10.00
    3173 50 4 1 1 0 0 0 0 6 0.12 0.10 8.00 6.00
    3174 50 11 3 1 0 0 0 0 15 0.30 0.24 16.00 14.00
    3175 50 12 2 2 0 1 0 1 18 0.36 0.32 26.00 22.00
    3176 50 8 5 0 0 0 0 0 13 0.26 0.16 20.00 14.00
    3177 50 8 1 0 0 0 0 0 9 0.18 0.16 16.00 14.00
Average         9.9 2.9 0.5 0.0 0.1 0.0 0.3 13.6 0.27 0.22 18.00 14.50
± SEM                         0.04 0.04 2.00 1.76
 
Test Chemical Methylenedianiline 
50         
 3130 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3131 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    3132 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3133 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3134 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3135 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3136 50 12 1 0 0 0 0 0 13 0.26 0.24 8.00 6.00
    3137 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         2.0 0.3 0.0 0.0 0.0 0.0 0.0 2.3 0.05 0.04 2.25 1.75
± SEM                         0.03 0.03 1.03 0.80
 
Test Chemical Methylenedianiline 
100         
 3140 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3141 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3142 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
    3143 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3144 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3145 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3146 50 0 1 1 0 0 0 0 2 0.04 0.02 4.00 2.00
    3147 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.6 0.3 0.1 0.0 0.0 0.0 0.0 1.0 0.02 0.02 1.75 1.25
± SEM                         0.01 0.01 0.59 0.37
 
Test Chemical Methylenedianiline 
200         
 3150 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3151 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3152 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3153 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3154 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    3155 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3156 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3157 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.50 1.00
± SEM                         0.01 0.01 0.73 0.76
 
Vehicle Control No Stressor 
 0         
 3160 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3161 50 1 0 0 0 0 0 2 3 0.06 0.06 4.00 4.00
    3162 50 0 0 0 0 0 0 1 1 0.02 0.02 2.00 2.00
    3163 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3164 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3165 50 4 0 0 0 0 0 0 4 0.08 0.08 4.00 4.00
    3166 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3167 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 0.1 0.0 0.0 0.0 0.0 0.4 1.4 0.03 0.03 2.00 1.75
± SEM                         0.01 0.01 0.53 0.59
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation