| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02466-0005-0000-5 |
| Chemical Name: | Methylenedianiline |
| CASRN: | 101-77-9 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 535562_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 02/06/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Dimethyl Sulfoxide |
0 |
3211 | 25 | 3.50 | ± | 0.388 |
| 3212 | 25 | 4.54 | ± | 0.335 | |||
| 3213 | 25 | 5.23 | ± | 0.437 | |||
| 3214 | 25 | 3.71 | ± | 0.380 | |||
| Average | 4.25 | ± | 0.398 | ||||
| Test Chemical | Methylenedianiline |
50 |
3195 | 25 | 8.76 | ± | 0.910 |
| 3196 | 25 | 6.56 | ± | 0.757 | |||
| 3197 | 25 | 5.34 | ± | 0.471 | |||
| 3198 | 25 | 6.18 | ± | 0.612 | |||
| Average | 6.72 | ± | 0.730 | ||||
| Test Chemical | Methylenedianiline |
100 |
3200 | 25 | 3.48 | ± | 0.299 |
| 3201 | 25 | 4.07 | ± | 0.460 | |||
| 3202 | 25 | 6.75 | ± | 0.621 | |||
| 3203 | 25 | 4.50 | ± | 0.329 | |||
| Average | 4.70 | ± | 0.715 | ||||
| Test Chemical | Methylenedianiline |
200 |
3205 | 25 | 4.39 | ± | 0.378 |
| 3206 | 25 | 4.41 | ± | 0.426 | |||
| 3207 | 25 | 3.68 | ± | 0.309 | |||
| 3208 | 25 | 4.22 | ± | 0.413 | |||
| Average | 4.17 | ± | 0.170 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
3215 | 25 | 8.00 | ± | 0.840 |
| 3216 | 25 | 6.86 | ± | 0.478 | |||
| 3217 | 25 | 9.48 | ± | 0.780 | |||
| 3218 | 25 | 6.92 | ± | 0.744 | |||
| Average | 7.82 | ± | 0.612 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed