| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02466-0005-0000-5 |
| Chemical Name: | Methylenedianiline |
| CASRN: | 101-77-9 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 535562_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 09/30/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Dimethyl Sulfoxide |
0 |
4309 | 25 | 5.89 | ± | 0.627 |
| 4310 | 25 | 3.17 | ± | 0.398 | |||
| 4311 | 25 | 2.29 | ± | 0.372 | |||
| 4312 | 25 | 4.25 | ± | 0.504 | |||
| Average | 3.90 | ± | 0.774 | ||||
| Test Chemical | Methylenedianiline |
50 |
4304 | 25 | 5.33 | ± | 0.477 |
| 4305 | 25 | 4.52 | ± | 0.424 | |||
| 4306 | 25 | 5.64 | ± | 0.580 | |||
| 4307 | 25 | 4.30 | ± | 0.632 | |||
| Average | 4.95 | ± | 0.319 | ||||
| Test Chemical | Methylenedianiline |
100 |
4299 | 25 | 4.73 | ± | 0.362 |
| 4300 | 25 | 5.38 | ± | 0.603 | |||
| 4301 | 25 | 5.46 | ± | 0.627 | |||
| 4302 | 25 | 5.56 | ± | 0.539 | |||
| Average | 5.28 | ± | 0.186 | ||||
| Test Chemical | Methylenedianiline |
200 |
4294 | 25 | 5.26 | ± | 0.461 |
| 4295 | 25 | 8.70 | ± | 0.884 | |||
| 4296 | 25 | 5.58 | ± | 0.639 | |||
| 4297 | 25 | 5.88 | ± | 0.426 | |||
| Average | 6.35 | ± | 0.792 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
4314 | 25 | 11.16 | ± | 1.394 |
| 4315 | 25 | 9.13 | ± | 1.075 | |||
| 4316 | 25 | 8.25 | ± | 0.739 | |||
| 4317 | 25 | 6.42 | ± | 0.677 | |||
| Average | 8.73 | ± | 0.984 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed