| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02466-0005-0000-5 |
| Chemical Name: | Methylenedianiline |
| CASRN: | 101-77-9 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 535562_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 09/06/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Dimethyl Sulfoxide |
0 |
8653 | 25 | 6.23 | ± | 0.731 |
| 8654 | 25 | 4.02 | ± | 0.395 | |||
| 8655 | 25 | 4.25 | ± | 0.482 | |||
| 8656 | 25 | 5.42 | ± | 0.554 | |||
| Average | 4.97 | ± | 0.517 | ||||
| Test Chemical | Methylenedianiline |
35 |
8628 | 25 | 4.29 | ± | 0.588 |
| 8629 | 25 | 3.78 | ± | 0.536 | |||
| 8630 | 25 | 3.17 | ± | 0.305 | |||
| 8631 | 25 | 3.69 | ± | 0.364 | |||
| Average | 3.73 | ± | 0.230 | ||||
| Test Chemical | Methylenedianiline |
70 |
8633 | 25 | 3.45 | ± | 0.360 |
| 8634 | 25 | 2.48 | ± | 0.284 | |||
| 8635 | 25 | 3.52 | ± | 0.311 | |||
| 8636 | 25 | 4.17 | ± | 0.524 | |||
| Average | 3.41 | ± | 0.349 | ||||
| Test Chemical | Methylenedianiline |
140 |
8638 | 25 | 7.10 | ± | 0.625 |
| 8639 | 25 | 6.83 | ± | 0.794 | |||
| 8640 | 25 | 6.40 | ± | 0.508 | |||
| 8641 | 25 | 5.41 | ± | 0.509 | |||
| Average | 6.44 | ± | 0.372 | ||||
| Positive Control | Dimethylbenzanthracene |
50 |
8658 | 25 | 17.22 | ± | 1.143 |
| 8659 | 25 | 18.66 | ± | 1.411 | |||
| 8660 | 25 | 12.99 | ± | 0.915 | |||
| 8661 | 25 | 16.42 | ± | 1.297 | |||
| Average | 16.33 | ± | 1.202 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed