| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02466-0005-0000-5 |
| Chemical Name: | Methylenedianiline |
| CASRN: | 101-77-9 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 535562_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 10/11/1988 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Dimethyl Sulfoxide |
0 |
8598 | 25 | 5.04 | ± | 0.570 |
| 8599 | 25 | 4.57 | ± | 0.461 | |||
| 8600 | 25 | 5.24 | ± | 0.664 | |||
| 8601 | 25 | 2.72 | ± | 0.339 | |||
| Average | 4.39 | ± | 0.575 | ||||
| Test Chemical | Methylenedianiline |
50 |
8568 | 25 | 3.89 | ± | 0.357 |
| 8569 | 25 | 4.83 | ± | 0.527 | |||
| 8570 | 25 | 4.92 | ± | 0.424 | |||
| 8571 | 25 | 5.21 | ± | 0.499 | |||
| Average | 4.71 | ± | 0.287 | ||||
| Test Chemical | Methylenedianiline |
100 |
8573 | 25 | 5.49 | ± | 0.411 |
| 8574 | 25 | 6.64 | ± | 0.700 | |||
| 8575 | 25 | 3.88 | ± | 0.484 | |||
| 8576 | 25 | 4.57 | ± | 0.487 | |||
| Average | 5.15 | ± | 0.598 | ||||
| Test Chemical | Methylenedianiline |
200 |
8578 | 25 | 8.84 | ± | 0.733 |
| 8579 | 25 | 7.08 | ± | 0.614 | |||
| 8580 | 25 | 7.77 | ± | 0.747 | |||
| 8581 | 25 | 8.20 | ± | 0.494 | |||
| Average | 7.98 | ± | 0.370 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
8603 | 25 | 10.01 | ± | 0.958 |
| 8604 | 25 | 14.90 | ± | 1.292 | |||
| 8605 | 25 | 9.64 | ± | 0.945 | |||
| 8606 | 25 | 11.13 | ± | 0.720 | |||
| Average | 11.43 | ± | 1.203 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed