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Study Information
Study Attribute Value
CEBS Accession Number: 002-01212-0011-0000-0
Chemical Name: 2,4- & 2,6-Toluene diisocyanate
CASRN: 26471-62-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 544551_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/29/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 11555 50 2 9 0 1 1 0 0 13 0.26 0.06 18.00 8.00
    11566 50 2 4 0 1 0 0 0 7 0.14 0.04 14.00 4.00
    11578 50 6 7 0 0 0 0 0 13 0.26 0.12 20.00 12.00
    11602 50 5 9 0 0 0 0 0 14 0.28 0.10 18.00 8.00
    11608 50 9 6 0 1 0 0 0 16 0.32 0.18 24.00 14.00
    11609 50 7 7 0 0 0 0 0 14 0.28 0.14 26.00 12.00
    11619 50 4 8 0 0 0 0 0 12 0.24 0.08 18.00 6.00
    11627 50 6 12 0 2 0 0 0 20 0.40 0.12 32.00 12.00
Average         5.1 7.8 0.0 0.6 0.1 0.0 0.0 13.6 0.27 0.11 21.25 9.50
± SEM                         0.03 0.02 2.03 1.24
 
Test Chemical 2,4- & 2,6-Toluene diisocyanate 
25         
 11559 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    11560 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11574 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    11579 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11582 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11584 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11587 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    11589 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
Average         0.6 1.6 0.0 0.0 0.0 0.0 0.1 2.4 0.05 0.02 4.00 1.25
± SEM                         0.01 0.01 0.76 0.65
 
Test Chemical 2,4- & 2,6-Toluene diisocyanate 
50         
 11557 50 0 16 0 0 0 0 0 16 0.32 0.00 0.00 0.00
    11567 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11572 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    11575 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11577 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11585 50 0 4 0 0 0 0 0 4 0.08 0.00 4.00 0.00
    11591 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11592 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
Average         0.4 3.6 0.0 0.0 0.0 0.0 0.0 4.0 0.08 0.01 3.25 0.75
± SEM                         0.04 0.00 1.00 0.37
 
Test Chemical 2,4- & 2,6-Toluene diisocyanate 
100         
 11561 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11563 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11564 50 0 2 0 0 0 0 1 3 0.06 0.02 2.00 0.00
    11569 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11571 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    11573 50 1 3 0 0 0 0 1 5 0.10 0.04 6.00 2.00
    11581 50 2 11 0 0 0 0 0 13 0.26 0.04 16.00 4.00
    11583 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.9 2.8 0.0 0.0 0.0 0.0 0.3 3.9 0.08 0.02 5.25 1.75
± SEM                         0.03 0.01 1.64 0.59
 
Vehicle Control No Stressor 
 0         
 11565 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11568 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    11588 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11599 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11606 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    11612 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11617 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11626 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.6 1.8 0.0 0.0 0.0 0.0 0.0 2.4 0.05 0.01 4.75 1.25
± SEM                         0.01 0.00 0.75 0.37
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation