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Study Information
Study Attribute Value
CEBS Accession Number: 002-01212-0011-0000-0
Chemical Name: 2,4- & 2,6-Toluene diisocyanate
CASRN: 26471-62-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 544551_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
04/11/1989 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 11666 50 28 11 0 0 1 0 0 40 0.80 0.58 30.00 18.00
    11669 50 24 9 0 0 0 1 0 34 0.68 0.50 30.00 20.00
    11697 50 26 9 0 0 0 1 1 37 0.74 0.56 24.00 12.00
    11702 50 10 11 0 0 0 0 0 21 0.42 0.20 22.00 10.00
    11721 50 52 6 0 0 0 0 1 59 1.18 1.06 32.00 26.00
    11724 50 14 4 0 0 0 0 0 18 0.36 0.28 12.00 8.00
    11729 50 24 10 0 0 0 0 1 35 0.70 0.50 18.00 14.00
Average         25.4 8.6 0.0 0.0 0.1 0.3 0.4 34.9 0.70 0.53 24.00 15.43
± SEM                         0.10 0.10 2.76 2.38
 
Test Chemical 2,4- & 2,6-Toluene diisocyanate 
25         
 11664 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11671 50 1 5 0 0 0 0 0 6 0.12 0.02 10.00 2.00
    11674 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11678 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11682 50 0 4 0 0 0 0 0 4 0.08 0.00 6.00 0.00
    11683 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11686 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11687 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 2.00
Average         0.1 1.5 0.0 0.0 0.0 0.0 0.0 1.6 0.03 0.00 2.75 0.50
± SEM                         0.02 0.00 1.25 0.33
 
Test Chemical 2,4- & 2,6-Toluene diisocyanate 
50         
 11659 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    11662 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    11665 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11670 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11673 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11679 50 0 2 0 0 0 0 1 3 0.06 0.02 2.00 0.00
    11680 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11684 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
Average         0.8 1.3 0.0 0.0 0.0 0.0 0.1 2.1 0.04 0.02 3.00 1.25
± SEM                         0.01 0.00 0.65 0.37
 
Test Chemical 2,4- & 2,6-Toluene diisocyanate 
100         
 11663 50 0 4 0 0 0 0 0 4 0.08 0.00 6.00 0.00
    11667 50 4 0 0 0 0 0 0 4 0.08 0.08 2.00 2.00
    11675 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11681 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11688 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11689 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11691 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11692 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.9 1.0 0.0 0.0 0.0 0.0 0.0 1.9 0.04 0.02 2.75 1.00
± SEM                         0.01 0.01 0.53 0.38
 
Vehicle Control No Stressor 
 0         
 11660 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    11685 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11690 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11696 50 0 0 0 0 0 0 0 0 0.00 0.00 4.00 4.00
    11698 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    11716 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    11722 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11725 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 0.8 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.02 3.00 2.00
± SEM                         0.01 0.01 0.65 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation