| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01212-0010-0000-9 |
| Chemical Name: | 2,4- & 2,6-Toluene diisocyanate |
| CASRN: | 26471-62-5 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 544551_SCE |
| Study Result: | Positive (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 12/20/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
10765 | 25 | 6.31 | ± | 0.447 |
| 10776 | 25 | 6.22 | ± | 0.595 | |||
| 10792 | 25 | 5.60 | ± | 0.337 | |||
| 10799 | 25 | 5.53 | ± | 0.527 | |||
| Average | 5.92 | ± | 0.203 | ||||
| Test Chemical | 2,4- & 2,6-Toluene diisocyanate |
25 |
10787 | 25 | 6.04 | ± | 0.584 |
| 10790 | 25 | 10.69 | ± | 0.935 | |||
| 10793 | 25 | 8.10 | ± | 0.910 | |||
| 10803 | 25 | 9.87 | ± | 0.873 | |||
| Average | 8.68 | ± | 1.030 | ||||
| Test Chemical | 2,4- & 2,6-Toluene diisocyanate |
50 |
10791 | 25 | 8.86 | ± | 0.613 |
| 10795 | 25 | 8.05 | ± | 0.520 | |||
| 10797 | 25 | 8.48 | ± | 0.676 | |||
| 10802 | 25 | 7.42 | ± | 0.472 | |||
| Average | 8.21 | ± | 0.309 | ||||
| Test Chemical | 2,4- & 2,6-Toluene diisocyanate |
100 |
10788 | 25 | 9.05 | ± | 0.619 |
| 10789 | 25 | 6.96 | ± | 0.558 | |||
| 10796 | 25 | 6.44 | ± | 0.804 | |||
| 10800 | 25 | 8.06 | ± | 0.587 | |||
| Average | 7.63 | ± | 0.581 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
10770 | 25 | 17.79 | ± | 1.743 |
| 10779 | 25 | 21.08 | ± | 1.406 | |||
| 10786 | 25 | 18.78 | ± | 1.222 | |||
| 10806 | 25 | 19.06 | ± | 1.871 | |||
| Average | 19.18 | ± | 0.690 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed