| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01212-0010-0000-9 |
| Chemical Name: | 2,4- & 2,6-Toluene diisocyanate |
| CASRN: | 26471-62-5 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 544551_SCE |
| Study Result: | Positive (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 03/14/1989 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
11423 | 25 | 4.88 | ± | 0.410 |
| 11432 | 25 | 5.84 | ± | 0.562 | |||
| 11437 | 24 | 6.38 | ± | 0.492 | |||
| 11451 | 25 | 4.92 | ± | 0.486 | |||
| Average | 5.49 | ± | 0.365 | ||||
| Test Chemical | 2,4- & 2,6-Toluene diisocyanate |
12.5 |
11453 | 24 | 7.50 | ± | 1.228 |
| 11461 | 24 | 5.79 | ± | 0.496 | |||
| 11462 | 25 | 6.09 | ± | 0.462 | |||
| 11464 | 24 | 4.96 | ± | 0.557 | |||
| Average | 6.08 | ± | 0.529 | ||||
| Test Chemical | 2,4- & 2,6-Toluene diisocyanate |
25 |
11450 | 25 | 6.57 | ± | 0.534 |
| 11456 | 25 | 5.12 | ± | 0.488 | |||
| 11465 | 24 | 5.25 | ± | 0.581 | |||
| 11466 | 25 | 6.00 | ± | 0.574 | |||
| Average | 5.74 | ± | 0.339 | ||||
| Test Chemical | 2,4- & 2,6-Toluene diisocyanate |
50 |
11449 | 25 | 5.60 | ± | 0.383 |
| 11460 | 25 | 6.96 | ± | 1.493 | |||
| 11463 | 25 | 5.08 | ± | 0.439 | |||
| 11467 | 25 | 4.52 | ± | 0.666 | |||
| Average | 5.23 | ± | 0.522 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
11428 | 25 | 9.95 | ± | 0.867 |
| 11431 | 25 | 12.36 | ± | 1.122 | |||
| 11454 | 25 | 13.52 | ± | 1.395 | |||
| 11458 | 25 | 15.40 | ± | 1.224 | |||
| Average | 12.81 | ± | 1.140 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed