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Study Information
Study Attribute Value
CEBS Accession Number: 002-01604-0029-0000-4
Chemical Name: Acrylamide
CASRN: 79-06-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 549305_CA
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/05/1985 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 2862 50 3 0 1 0 0 0 0 4 0.08 0.08 8.00 8.00
    2866 50 2 0 0 0 0 0 1 3 0.06 0.06 4.00 4.00
    2873 50 2 1 0 0 0 0 0 3 0.06 0.04 2.00 2.00
    2879 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    2886 50 4 1 1 0 0 0 1 7 0.14 0.12 12.00 10.00
    2890 50 4 2 0 0 0 0 0 6 0.12 0.08 10.00 8.00
    2896 50 6 4 0 0 0 0 0 10 0.20 0.12 16.00 10.00
    2902 50 4 2 0 0 0 0 1 7 0.14 0.10 12.00 8.00
Average         3.3 1.4 0.3 0.0 0.0 0.0 0.4 5.3 0.11 0.08 8.50 6.50
± SEM                         0.02 0.01 1.72 1.18
 
Test Chemical Acrylamide 
40         
 2874 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2881 50 3 0 0 0 0 0 1 4 0.08 0.08 6.00 6.00
    2883 50 4 4 0 0 0 0 1 9 0.18 0.10 12.00 8.00
    2893 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    2901 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    2905 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2906 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.4 1.1 0.0 0.0 0.0 0.0 0.3 2.9 0.06 0.03 4.29 2.86
± SEM                         0.03 0.02 1.77 1.22
 
Test Chemical Acrylamide 
80         
 2861 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2875 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    2878 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    2897 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2900 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    2904 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    2908 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
Average         0.6 1.0 0.0 0.0 0.0 0.0 0.3 1.9 0.04 0.02 2.86 1.14
± SEM                         0.01 0.01 0.96 0.59
 
Test Chemical Acrylamide 
160         
 2863 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    2867 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    2870 50 2 0 0 0 0 0 1 3 0.06 0.06 6.00 6.00
    2876 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    2885 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2887 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 4.00
    2891 50 2 0 0 0 0 0 2 4 0.08 0.08 8.00 8.00
    2907 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.6 0.5 0.0 0.0 0.0 0.0 0.4 2.5 0.05 0.04 5.00 4.25
± SEM                         0.01 0.01 0.85 1.03
 
Vehicle Control No Stressor 
 0         
 2864 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2865 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    2872 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2877 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    2880 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    2884 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2895 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2898 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.6 0.0 0.0 0.0 0.0 0.1 1.3 0.03 0.01 2.00 1.00
± SEM                         0.01 0.01 1.00 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation