| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01604-0028-0000-3 |
| Chemical Name: | Acrylamide |
| CASRN: | 79-06-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 549305_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 11/14/1985 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
2842 | 25 | 3.64 | ± | 0.293 |
| 2846 | 25 | 4.41 | ± | 0.524 | |||
| 2850 | 25 | 3.83 | ± | 0.361 | |||
| 2856 | 25 | 3.81 | ± | 0.461 | |||
| Average | 3.93 | ± | 0.168 | ||||
| Test Chemical | Acrylamide |
40 |
2832 | 25 | 8.73 | ± | 0.938 |
| 2839 | 25 | 7.85 | ± | 0.638 | |||
| 2852 | 25 | 9.39 | ± | 0.678 | |||
| 2858 | 25 | 6.20 | ± | 0.763 | |||
| Average | 8.04 | ± | 0.691 | ||||
| Test Chemical | Acrylamide |
80 |
2833 | 25 | 8.04 | ± | 0.748 |
| 2843 | 24 | 8.79 | ± | 0.883 | |||
| 2848 | 25 | 8.25 | ± | 0.754 | |||
| 2853 | 25 | 9.92 | ± | 0.958 | |||
| Average | 8.75 | ± | 0.419 | ||||
| Test Chemical | Acrylamide |
160 |
2836 | 25 | 14.84 | ± | 1.201 |
| 2837 | 25 | 12.41 | ± | 0.838 | |||
| 2855 | 25 | 13.60 | ± | 1.174 | |||
| 2860 | 25 | 14.75 | ± | 0.954 | |||
| Average | 13.91 | ± | 0.570 | ||||
| Positive Control | Mitomycin-C |
0.5 |
2831 | 25 | 10.46 | ± | 0.579 |
| 2835 | 25 | 7.29 | ± | 0.876 | |||
| 2841 | 25 | 9.37 | ± | 0.751 | |||
| 2849 | 25 | 10.46 | ± | 0.946 | |||
| Average | 9.40 | ± | 0.748 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed