| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01604-0028-0000-3 |
| Chemical Name: | Acrylamide |
| CASRN: | 79-06-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 549305_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 08/18/1987 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
5965 | 25 | 3.36 | ± | 0.347 |
| 5978 | 25 | 6.46 | ± | 0.654 | |||
| 5992 | 24 | 5.70 | ± | 0.570 | |||
| Average | 5.17 | ± | 0.932 | ||||
| Test Chemical | Acrylamide |
40 |
5966 | 25 | 5.88 | ± | 0.540 |
| 5982 | 26 | 4.67 | ± | 0.351 | |||
| 6006 | 25 | 8.57 | ± | 1.105 | |||
| 6018 | 25 | 5.66 | ± | 0.525 | |||
| Average | 6.18 | ± | 0.834 | ||||
| Test Chemical | Acrylamide |
80 |
5956 | 25 | 7.18 | ± | 0.607 |
| 5957 | 25 | 6.95 | ± | 0.499 | |||
| 6008 | 25 | 6.79 | ± | 0.542 | |||
| 6020 | 25 | 6.78 | ± | 0.533 | |||
| Average | 6.94 | ± | 0.095 | ||||
| Test Chemical | Acrylamide |
160 |
5948 | 25 | 9.14 | ± | 0.596 |
| 5985 | 25 | 9.11 | ± | 0.718 | |||
| 6016 | 25 | 10.01 | ± | 0.679 | |||
| Average | 9.42 | ± | 0.295 | ||||
| Positive Control | Mitomycin-C |
0.5 |
5946 | 24 | 4.42 | ± | 0.421 |
| 5975 | 24 | 3.83 | ± | 0.360 | |||
| 6000 | 23 | 3.80 | ± | 0.477 | |||
| 6017 | 25 | 3.91 | ± | 0.345 | |||
| Average | 4.00 | ± | 0.145 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed