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Study Information
Study Attribute Value
CEBS Accession Number: 002-03058-0022-0000-2
Chemical Name: trans-1,2-Dichloroethylene
CASRN: 156-60-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 560707_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/23/1985 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 1873 50 17 9 0 1 0 0 1 28 0.56 0.36 28.00 22.00
    1874 50 24 4 1 0 0 0 1 30 0.60 0.52 36.00 32.00
    1875 50 11 0 1 0 0 0 0 12 0.24 0.24 18.00 18.00
    1876 50 3 4 0 0 1 0 0 8 0.16 0.08 10.00 6.00
    1877 50 19 3 1 0 1 0 0 24 0.48 0.42 24.00 20.00
    1878 50 26 2 1 1 0 0 0 30 0.60 0.54 30.00 28.00
    1879 50 10 5 6 0 2 0 0 23 0.46 0.36 32.00 26.00
    1880 50 8 2 1 0 0 0 0 11 0.22 0.18 18.00 16.00
Average         14.8 3.6 1.4 0.3 0.5 0.0 0.3 20.8 0.42 0.34 24.50 21.00
± SEM                         0.06 0.06 3.06 2.85
 
Test Chemical trans-1,2-Dichloroethylene 
500         
 1863 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    1864 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1865 50 7 0 0 0 0 0 0 7 0.14 0.14 8.00 8.00
    1866 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    1867 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1868 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    1869 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1870 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.3 0.3 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.03 2.25 1.75
± SEM                         0.02 0.02 0.96 1.03
 
Test Chemical trans-1,2-Dichloroethylene 
1000         
 1853 50 4 0 0 0 0 0 0 4 0.08 0.08 6.00 6.00
    1854 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1855 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    1856 50 9 4 0 0 0 0 1 14 0.28 0.20 18.00 16.00
    1857 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    1858 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1859 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1860 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         2.0 0.5 0.1 0.0 0.0 0.0 0.1 2.8 0.06 0.05 4.00 3.75
± SEM                         0.03 0.02 2.14 1.91
 
Test Chemical trans-1,2-Dichloroethylene 
2000         
 1843 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1844 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1845 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1846 50 2 0 1 0 0 0 0 3 0.06 0.06 6.00 6.00
    1847 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1848 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1849 50 2 0 1 0 0 0 1 4 0.08 0.08 4.00 4.00
    1850 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.8 0.0 0.3 0.0 0.0 0.0 0.1 1.1 0.02 0.02 1.75 1.75
± SEM                         0.01 0.01 0.80 0.80
 
Vehicle Control No Stressor 
 0         
 1913 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    1914 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1915 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1916 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1917 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1918 50 1 1 0 1 0 0 1 4 0.08 0.04 8.00 4.00
    1919 50 0 1 1 0 0 0 0 2 0.04 0.02 4.00 2.00
    1920 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.9 0.3 0.1 0.1 0.0 0.0 0.1 1.5 0.03 0.02 3.00 2.25
± SEM                         0.01 0.00 0.85 0.45
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation