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Study Information
Study Attribute Value
CEBS Accession Number: 002-03058-0021-0000-1
Chemical Name: trans-1,2-Dichloroethylene
CASRN: 156-60-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 560707_SCE
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.


Detailed Sister Chromatid Exchange Data (Trial 1)
Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Trial Result
03/20/1985 Bone Marrow 23 Male Mouse B6C3F1 IP/IJ x 1,  23 hour Negative (Nonstandard Protocol)

Test Group Dose
(mg/kg)		 Animal
Number		 No.
Cells		 SCE / Cell
Mean ± SEM
Vehicle Control Corn Oil 
 0         
 2082 25 2.36 ± 0.251
    2083 25 2.92 ± 0.346
    2084 25 4.12 ± 0.376
    2085 25 4.05 ± 0.366
Average   3.37 ± 0.432
 
Test Chemical trans-1,2-Dichloroethylene 
500         
 2052 25 4.31 ± 0.498
    2053 25 3.61 ± 0.390
    2054 25 3.29 ± 0.425
    2055 25 2.97 ± 0.315
Average   3.55 ± 0.288
 
Test Chemical trans-1,2-Dichloroethylene 
1000         
 2057 25 2.84 ± 0.330
    2058 25 3.60 ± 0.444
    2059 25 3.72 ± 0.368
    2060 25 3.36 ± 0.420
Average   3.38 ± 0.196
 
Test Chemical trans-1,2-Dichloroethylene 
2000         
 2062 25 3.02 ± 0.357
    2063 25 2.69 ± 0.663
    2065 25 3.13 ± 0.420
    2066 25 3.16 ± 0.319
Average   3.00 ± 0.108
 
Positive Control Dimethylbenzanthracene 
100         
 2087 25 14.11 ± 1.123
    2088 25 10.78 ± 0.814
    2089 25 15.24 ± 1.363
    2090 25 13.02 ± 1.329
Average   13.27 ± 0.951
 

Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed