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Study Information
Study Attribute Value
CEBS Accession Number: 002-01436-0015-0000-2
Chemical Name: 3-Chloromethylpyridine hydrochloride
CASRN: 6959-48-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 562806_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/10/1985 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
 0.5       
 2334 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    2335 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    2336 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2337 50 0 1 1 0 0 0 0 2 0.04 0.02 4.00 2.00
    2338 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2339 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    2340 50 1 0 0 0 0 0 0 1 0.02 0.02 6.00 6.00
    2341 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.1 0.8 0.1 0.0 0.0 0.0 0.0 2.0 0.04 0.03 4.50 3.00
± SEM                         0.01 0.00 0.91 0.53
 
Test Chemical 3-Chloromethylpyridine hydrochloride 
75         
 2278 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2279 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2280 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    2281 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    2282 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2283 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2284 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    2285 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.3 0.0 0.0 0.0 0.0 0.0 0.9 0.02 0.01 1.75 1.25
± SEM                         0.01 0.01 0.70 0.53
 
Test Chemical 3-Chloromethylpyridine hydrochloride 
150         
 2286 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2287 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2288 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2289 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2290 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2291 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2292 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2293 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.4 0.01 0.00 0.75 0.25
± SEM                         0.00 0.00 0.37 0.25
 
Test Chemical 3-Chloromethylpyridine hydrochloride 
300         
 2294 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2295 50 0 1 0 1 0 0 0 2 0.04 0.00 4.00 0.00
    2296 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2297 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2298 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2299 50 0 1 0 0 0 0 11 12 0.24 0.22 4.00 2.00
    2300 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2301 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.0 0.4 0.0 0.1 0.0 0.0 1.4 1.9 0.04 0.03 1.25 0.25
± SEM                         0.03 0.03 0.65 0.25
 
Vehicle Control No Stressor 
 0         
 2326 50 0 0 0 1 0 0 0 1 0.02 0.00 2.00 0.00
    2327 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2328 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    2329 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2330 50 3 0 0 0 0 0 0 3 0.06 0.06 2.00 2.00
    2331 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2332 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2333 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.5 0.4 0.0 0.1 0.0 0.0 0.1 1.1 0.02 0.01 1.50 0.50
± SEM                         0.01 0.01 0.33 0.33
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation