| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01048-0012-0000-8 |
| Chemical Name: | 1,2-Dichloropropane (propylene dichloride) |
| CASRN: | 78-87-5 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 568899_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 06/11/1990 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
11050 | 25 | 4.66 | ± | 0.390 |
| 11051 | 25 | 5.17 | ± | 0.441 | |||
| 11052 | 25 | 4.60 | ± | 0.391 | |||
| 11053 | 25 | 5.13 | ± | 0.532 | |||
| Average | 4.89 | ± | 0.151 | ||||
| Test Chemical | 1,2-Dichloropropane (propylene dichloride) |
112.5 |
11035 | 25 | 3.80 | ± | 0.454 |
| 11036 | 25 | 4.60 | ± | 0.383 | |||
| 11037 | 25 | 3.88 | ± | 0.348 | |||
| 11038 | 25 | 5.44 | ± | 0.494 | |||
| Average | 4.43 | ± | 0.381 | ||||
| Test Chemical | 1,2-Dichloropropane (propylene dichloride) |
225 |
11040 | 25 | 6.09 | ± | 0.574 |
| 11041 | 25 | 4.12 | ± | 0.425 | |||
| 11042 | 25 | 3.52 | ± | 0.490 | |||
| 11043 | 25 | 3.08 | ± | 0.374 | |||
| Average | 4.20 | ± | 0.664 | ||||
| Test Chemical | 1,2-Dichloropropane (propylene dichloride) |
450 |
11046 | 25 | 4.40 | ± | 0.383 |
| 11047 | 25 | 3.57 | ± | 0.300 | |||
| 11048 | 25 | 3.94 | ± | 0.458 | |||
| 11049 | 25 | 3.38 | ± | 0.307 | |||
| Average | 3.82 | ± | 0.225 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
11055 | 25 | 10.63 | ± | 1.110 |
| 11056 | 25 | 11.46 | ± | 0.981 | |||
| 11057 | 25 | 11.23 | ± | 0.983 | |||
| 11058 | 25 | 11.11 | ± | 0.902 | |||
| Average | 11.11 | ± | 0.175 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed