| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01048-0012-0000-8 |
| Chemical Name: | 1,2-Dichloropropane (propylene dichloride) |
| CASRN: | 78-87-5 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 568899_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 01/27/1987 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
4995 | 25 | 4.55 | ± | 0.374 |
| 4996 | 25 | 5.49 | ± | 0.388 | |||
| 4997 | 25 | 5.34 | ± | 0.504 | |||
| 4998 | 25 | 6.00 | ± | 0.520 | |||
| Average | 5.35 | ± | 0.299 | ||||
| Test Chemical | 1,2-Dichloropropane (propylene dichloride) |
112.5 |
4980 | 25 | 3.65 | ± | 0.435 |
| 4981 | 25 | 2.84 | ± | 0.407 | |||
| 4982 | 25 | 3.79 | ± | 0.371 | |||
| 4983 | 25 | 2.32 | ± | 0.281 | |||
| Average | 3.15 | ± | 0.345 | ||||
| Test Chemical | 1,2-Dichloropropane (propylene dichloride) |
225 |
4985 | 25 | 4.53 | ± | 0.429 |
| 4986 | 25 | 5.81 | ± | 0.539 | |||
| 4987 | 25 | 4.00 | ± | 0.315 | |||
| 4988 | 25 | 4.93 | ± | 0.513 | |||
| Average | 4.82 | ± | 0.382 | ||||
| Test Chemical | 1,2-Dichloropropane (propylene dichloride) |
450 |
4990 | 25 | 5.02 | ± | 0.458 |
| 4991 | 25 | 4.85 | ± | 0.512 | |||
| 4992 | 25 | 6.08 | ± | 0.500 | |||
| 4993 | 25 | 4.88 | ± | 0.425 | |||
| Average | 5.22 | ± | 0.293 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
5000 | 25 | 10.76 | ± | 0.833 |
| 5001 | 25 | 5.61 | ± | 0.623 | |||
| 5002 | 25 | 6.25 | ± | 0.470 | |||
| 5003 | 25 | 8.99 | ± | 1.044 | |||
| Average | 7.91 | ± | 1.201 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed