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Study Information
Study Attribute Value
CEBS Accession Number: 002-01863-0013-0000-4
Chemical Name: Chlorobenzene
CASRN: 108-90-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 569047_CA
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/08/1988 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 8770 50 7 1 0 0 0 0 1 9 0.18 0.16 16.00 14.00
    8776 50 5 7 0 1 0 0 0 13 0.26 0.10 18.00 10.00
    8790 50 8 9 0 1 0 0 0 18 0.36 0.16 32.00 16.00
    8795 50 6 11 0 0 0 0 1 18 0.36 0.14 30.00 12.00
    8809 50 8 10 0 0 0 0 0 18 0.36 0.16 26.00 14.00
    8814 50 6 7 0 0 0 0 0 13 0.26 0.12 22.00 12.00
    8825 50 7 18 0 0 0 0 0 25 0.50 0.14 30.00 8.00
    8830 50 12 8 0 0 0 0 0 20 0.40 0.24 30.00 22.00
Average         7.4 8.9 0.0 0.3 0.0 0.0 0.3 16.8 0.34 0.15 25.50 13.50
± SEM                         0.04 0.01 2.16 1.50
 
Test Chemical Chlorobenzene 
312.5       
 8805 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    8810 50 2 3 0 0 0 1 0 6 0.12 0.06 10.00 6.00
    8816 50 4 10 0 0 0 0 0 14 0.28 0.08 16.00 8.00
    8818 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    8820 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    8823 50 1 3 0 0 0 0 1 5 0.10 0.04 6.00 2.00
    8827 50 1 5 0 0 0 0 0 6 0.12 0.02 8.00 2.00
    8834 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
Average         1.5 3.9 0.0 0.0 0.0 0.1 0.1 5.6 0.11 0.04 7.75 3.25
± SEM                         0.03 0.01 1.39 0.92
 
Test Chemical Chlorobenzene 
625         
 8808 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    8812 50 3 3 0 0 0 0 0 6 0.12 0.06 8.00 4.00
    8815 50 2 5 0 0 0 0 0 7 0.14 0.04 12.00 4.00
    8817 50 0 5 0 0 0 0 0 5 0.10 0.00 8.00 0.00
    8829 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    8831 50 1 3 0 0 0 0 0 4 0.08 0.02 4.00 2.00
    8833 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8836 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.0 2.6 0.0 0.0 0.0 0.0 0.0 3.6 0.07 0.02 5.75 1.75
± SEM                         0.02 0.01 1.39 0.59
 
Test Chemical Chlorobenzene 
1250         
 8807 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8811 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    8813 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    8824 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    8826 50 2 4 0 0 0 0 0 6 0.12 0.04 6.00 4.00
    8828 50 0 3 0 0 0 0 1 4 0.08 0.02 6.00 0.00
    8841 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 1.7 0.0 0.0 0.0 0.0 0.1 2.7 0.05 0.02 4.29 1.71
± SEM                         0.01 0.01 0.92 0.68
 
Vehicle Control No Stressor 
 0         
 8769 50 2 7 0 0 0 0 0 9 0.18 0.04 8.00 4.00
    8781 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8785 50 0 5 0 0 0 0 0 5 0.10 0.00 6.00 0.00
    8789 50 1 0 0 1 0 0 0 2 0.04 0.02 2.00 2.00
    8796 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8806 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    8835 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    8838 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.5 2.1 0.0 0.1 0.0 0.0 0.0 2.8 0.06 0.01 3.50 1.00
± SEM                         0.02 0.01 0.91 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation