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Study Information
Study Attribute Value
CEBS Accession Number: 002-01863-0013-0000-4
Chemical Name: Chlorobenzene
CASRN: 108-90-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 569047_CA
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
10/26/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 10366 50 23 6 0 0 0 0 1 30 0.60 0.48 22.00 10.00
    10384 50 21 8 0 0 0 0 0 29 0.58 0.42 30.00 20.00
    10408 50 7 2 0 0 0 0 0 9 0.18 0.14 12.00 8.00
    10415 50 37 6 0 0 0 0 0 43 0.86 0.74 30.00 20.00
    10422 50 31 4 0 0 0 0 0 35 0.70 0.62 24.00 18.00
    10427 50 63 12 0 0 0 0 1 76 1.52 1.28 40.00 30.00
    10440 50 18 4 0 0 0 0 0 22 0.44 0.36 20.00 14.00
Average         28.6 6.0 0.0 0.0 0.0 0.0 0.3 34.9 0.70 0.58 25.43 17.14
± SEM                         0.16 0.14 3.37 2.79
 
Test Chemical Chlorobenzene 
250         
 10364 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10368 50 4 11 0 0 0 0 0 15 0.30 0.08 18.00 8.00
    10371 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    10375 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    10379 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10380 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
Average         1.3 3.5 0.0 0.0 0.0 0.0 0.2 5.0 0.10 0.03 7.67 2.67
± SEM                         0.04 0.01 2.22 1.12
 
Test Chemical Chlorobenzene 
500         
 10361 50 1 1 1 1 0 0 1 5 0.10 0.06 8.00 4.00
    10363 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10365 50 0 2 0 0 0 0 1 3 0.06 0.02 4.00 0.00
    10374 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    10377 50 4 5 0 0 0 0 0 9 0.18 0.08 14.00 8.00
    10378 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10388 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10389 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.0 1.5 0.1 0.1 0.0 0.0 0.3 3.0 0.06 0.03 5.00 2.25
± SEM                         0.02 0.01 1.56 0.96
 
Test Chemical Chlorobenzene 
1000         
 10362 50 2 1 0 0 0 0 1 4 0.08 0.06 6.00 4.00
    10369 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    10373 50 10 10 0 0 0 0 0 20 0.40 0.20 24.00 20.00
    10382 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    10383 50 4 2 0 0 0 0 0 6 0.12 0.08 8.00 6.00
    10385 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10386 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    10387 50 6 6 0 2 0 0 2 16 0.32 0.16 18.00 8.00
Average         3.0 3.4 0.0 0.3 0.0 0.0 0.4 7.0 0.14 0.07 9.50 5.25
± SEM                         0.05 0.03 2.64 2.33
 
Vehicle Control No Stressor 
 0         
 10367 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10372 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    10402 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10411 50 10 2 0 0 0 0 1 13 0.26 0.22 6.00 2.00
    10417 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    10430 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    10433 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10437 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.9 1.4 0.0 0.0 0.0 0.0 0.1 3.4 0.07 0.04 4.25 1.50
± SEM                         0.03 0.03 1.10 0.82
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation