| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01863-0012-0000-3 |
| Chemical Name: | Chlorobenzene |
| CASRN: | 108-90-7 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 569047_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 01/27/1988 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
7446 | 25 | 4.67 | ± | 0.378 |
| 7464 | 25 | 4.82 | ± | 0.482 | |||
| 7496 | 25 | 5.34 | ± | 0.508 | |||
| 7500 | 25 | 4.67 | ± | 0.417 | |||
| Average | 4.87 | ± | 0.160 | ||||
| Test Chemical | Chlorobenzene |
250 |
7482 | 25 | 5.88 | ± | 0.466 |
| 7483 | 25 | 4.39 | ± | 0.360 | |||
| 7484 | 25 | 4.21 | ± | 0.441 | |||
| 7487 | 25 | 5.34 | ± | 0.410 | |||
| Average | 4.96 | ± | 0.397 | ||||
| Test Chemical | Chlorobenzene |
500 |
7490 | 25 | 5.20 | ± | 0.529 |
| 7493 | 25 | 4.26 | ± | 0.405 | |||
| 7494 | 25 | 4.29 | ± | 0.379 | |||
| 7497 | 25 | 3.94 | ± | 0.332 | |||
| Average | 4.43 | ± | 0.270 | ||||
| Test Chemical | Chlorobenzene |
1000 |
7486 | 25 | 5.47 | ± | 0.471 |
| 7489 | 25 | 6.07 | ± | 0.707 | |||
| 7491 | 25 | 7.79 | ± | 0.886 | |||
| 7492 | 25 | 4.89 | ± | 0.426 | |||
| Average | 6.06 | ± | 0.627 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
7448 | 25 | 9.43 | ± | 0.812 |
| 7473 | 25 | 11.04 | ± | 0.615 | |||
| 7485 | 25 | 8.25 | ± | 0.580 | |||
| 7511 | 25 | 7.42 | ± | 0.663 | |||
| Average | 9.03 | ± | 0.784 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed