| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01863-0012-0000-3 |
| Chemical Name: | Chlorobenzene |
| CASRN: | 108-90-7 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 569047_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 03/02/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
7802 | 25 | 4.78 | ± | 0.434 |
| 7812 | 25 | 4.29 | ± | 0.419 | |||
| 7822 | 25 | 3.88 | ± | 0.422 | |||
| 7848 | 25 | 8.59 | ± | 0.788 | |||
| Average | 5.40 | ± | 1.084 | ||||
| Test Chemical | Chlorobenzene |
87.5 |
7837 | 25 | 10.91 | ± | 1.330 |
| 7843 | 25 | 8.04 | ± | 0.738 | |||
| 7846 | 25 | 6.97 | ± | 0.620 | |||
| 7849 | 25 | 6.72 | ± | 0.577 | |||
| Average | 8.17 | ± | 0.961 | ||||
| Test Chemical | Chlorobenzene |
175 |
7836 | 25 | 7.70 | ± | 0.906 |
| 7838 | 25 | 11.69 | ± | 1.207 | |||
| 7840 | 25 | 4.66 | ± | 0.313 | |||
| 7844 | 25 | 5.50 | ± | 0.440 | |||
| Average | 7.41 | ± | 1.571 | ||||
| Test Chemical | Chlorobenzene |
350 |
7832 | 25 | 5.54 | ± | 0.421 |
| 7833 | 25 | 4.51 | ± | 0.381 | |||
| 7841 | 25 | 8.05 | ± | 0.786 | |||
| 7851 | 25 | 4.76 | ± | 0.451 | |||
| Average | 5.70 | ± | 0.809 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
7797 | 25 | 13.47 | ± | 0.669 |
| 7811 | 25 | 15.09 | ± | 0.784 | |||
| 7829 | 25 | 11.80 | ± | 0.971 | |||
| 7834 | 25 | 14.43 | ± | 0.964 | |||
| Average | 13.69 | ± | 0.715 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed