| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01863-0012-0000-3 |
| Chemical Name: | Chlorobenzene |
| CASRN: | 108-90-7 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 569047_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 05/10/1988 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
8510 | 25 | 5.34 | ± | 0.529 |
| 8533 | 24 | 5.95 | ± | 0.540 | |||
| 8566 | 25 | 4.54 | ± | 0.393 | |||
| 8571 | 25 | 4.20 | ± | 0.356 | |||
| Average | 4.99 | ± | 0.394 | ||||
| Test Chemical | Chlorobenzene |
1000 |
8525 | 25 | 5.89 | ± | 0.512 |
| 8526 | 25 | 5.06 | ± | 0.465 | |||
| 8529 | 25 | 4.16 | ± | 0.366 | |||
| 8532 | 25 | 5.20 | ± | 0.611 | |||
| Average | 5.08 | ± | 0.356 | ||||
| Test Chemical | Chlorobenzene |
1250 |
8527 | 25 | 5.50 | ± | 0.468 |
| 8530 | 25 | 6.12 | ± | 0.794 | |||
| 8531 | 25 | 4.99 | ± | 0.592 | |||
| 8534 | 25 | 6.44 | ± | 0.716 | |||
| Average | 5.75 | ± | 0.324 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
8519 | 25 | 6.21 | ± | 0.533 |
| 8536 | 25 | 7.74 | ± | 0.683 | |||
| 8541 | 25 | 7.38 | ± | 0.575 | |||
| 8561 | 25 | 6.80 | ± | 0.521 | |||
| Average | 7.03 | ± | 0.335 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed