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Study Information
Study Attribute Value
CEBS Accession Number: 002-01091-0011-0000-5
Chemical Name: 1,4-Dichlorobenzene (p-dichlorobenzene)
CASRN: 106-46-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 576715_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
10/18/1990 Bone Marrow 17 Male Mouse B6C3F1 Gavage x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 230015 50 3 3 0 0 0 0 0 6 0.12 0.06 10.00 6.00
    230020 50 2 2 1 0 0 0 0 5 0.10 0.06 12.00 8.00
    230024 50 4 5 0 0 0 0 1 10 0.20 0.10 18.00 8.00
    230026 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    230027 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    230035 50 4 2 0 0 0 0 0 6 0.12 0.08 14.00 10.00
    230036 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    230038 50 7 9 1 0 0 0 0 17 0.34 0.16 20.00 12.00
    230039 50 5 5 0 0 0 0 0 10 0.20 0.10 18.00 10.00
    230049 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
Average         4.0 3.6 0.3 0.0 0.0 0.0 0.1 8.0 0.16 0.09 14.00 8.50
± SEM                         0.03 0.01 1.46 0.73
 
Test Chemical 1,4-Dichlorobenzene (p-dichlorobenzene) 
750         
 230009 50 0 1 1 0 0 0 0 2 0.04 0.02 4.00 2.00
    230010 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    230017 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    230031 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    230032 50 1 1 0 1 0 0 0 3 0.06 0.02 2.00 2.00
    230040 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    230042 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    230045 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    230046 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    230051 50 0 2 1 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         0.4 1.6 0.3 0.1 0.0 0.0 0.0 2.4 0.05 0.01 3.75 1.25
± SEM                         0.01 0.00 0.88 0.37
 
Test Chemical 1,4-Dichlorobenzene (p-dichlorobenzene) 
1500         
 230007 50 1 3 0 1 0 0 0 5 0.10 0.02 10.00 2.00
    230018 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    230019 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    230022 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    230023 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    230029 50 0 1 2 1 0 0 0 4 0.08 0.04 8.00 4.00
    230033 50 2 5 0 2 0 0 0 9 0.18 0.04 18.00 4.00
    230034 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    230041 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    230043 50 0 2 0 0 0 0 0 2 0.04 0.00 6.00 2.00
Average         0.8 1.9 0.4 0.5 0.0 0.0 0.0 3.5 0.07 0.02 7.00 2.50
± SEM                         0.02 0.00 1.85 0.33
 
Test Chemical 1,4-Dichlorobenzene (p-dichlorobenzene) 
3000         
 230003 50 0 2 0 1 0 0 0 3 0.06 0.00 6.00 0.00
    230004 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    230006 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    230008 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    230012 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    230037 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    230047 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    230048 50 0 0 0 1 0 0 0 1 0.02 0.00 2.00 0.00
    230050 50 1 1 1 0 0 0 0 3 0.06 0.04 6.00 4.00
    230052 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.0 0.6 0.1 0.3 0.0 0.0 0.0 2.0 0.04 0.02 4.00 2.25
± SEM                         0.01 0.01 0.85 0.70
 
Vehicle Control No Stressor 
 0         
 230005 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    230011 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    230014 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    230016 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    230021 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    230025 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    230028 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    230030 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    230044 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    230058 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.8 0.6 0.3 0.0 0.0 0.0 0.0 1.6 0.03 0.02 3.25 2.00
± SEM                         0.00 0.01 0.37 0.65
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation