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Study Information
Study Attribute Value
CEBS Accession Number: 002-01091-0011-0000-5
Chemical Name: 1,4-Dichlorobenzene (p-dichlorobenzene)
CASRN: 106-46-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 576715_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/18/1990 Bone Marrow 36 Male Mouse B6C3F1 Gavage x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 240005 50 5 2 0 0 0 0 1 8 0.16 0.12 14.00 12.00
    240010 50 3 2 0 0 0 0 4 9 0.18 0.14 14.00 10.00
    240011 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240018 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    240036 50 2 4 0 0 0 0 1 7 0.14 0.06 14.00 6.00
    240037 50 4 6 0 0 0 0 1 11 0.22 0.10 14.00 8.00
    240039 50 5 4 0 0 0 0 1 10 0.20 0.12 16.00 14.00
    240042 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    240050 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240052 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         3.0 2.5 0.0 0.0 0.0 0.0 1.0 6.5 0.13 0.08 10.75 7.50
± SEM                         0.03 0.02 1.96 1.59
 
Test Chemical 1,4-Dichlorobenzene (p-dichlorobenzene) 
750         
 240014 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    240019 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240021 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    240022 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240024 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240025 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    240028 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240033 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240035 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    240041 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.4 0.3 0.3 0.0 0.0 0.0 0.0 0.9 0.02 0.01 1.50 1.25
± SEM                         0.01 0.01 0.50 0.53
 
Test Chemical 1,4-Dichlorobenzene (p-dichlorobenzene) 
1500         
 240001 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240003 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    240004 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    240007 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 2.00
    240017 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240029 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    240032 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240034 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240047 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    240048 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.5 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.01 1.75 1.25
± SEM                         0.01 0.01 0.59 0.53
 
Test Chemical 1,4-Dichlorobenzene (p-dichlorobenzene) 
3000         
 240002 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    240006 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240008 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    240012 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240016 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240027 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240044 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240045 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240046 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240051 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.4 0.3 0.0 0.0 0.0 0.0 0.0 0.7 0.01 0.01 1.43 0.86
± SEM                         0.01 0.00 0.84 0.40
 
Vehicle Control No Stressor 
 0         
 240009 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240013 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    240015 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    240020 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240023 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    240026 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    240031 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240038 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240043 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    240049 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.1 0.1 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.25 1.25
± SEM                         0.01 0.01 0.65 0.65
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation