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Study Information
Study Attribute Value
CEBS Accession Number: 002-02340-0017-0000-9
Chemical Name: L-Ascorbic acid
CASRN: 50-81-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 592095_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/16/1988 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 9546 50 10 3 0 0 0 0 1 14 0.28 0.22 22.00 16.00
    9558 50 4 2 0 0 0 0 0 6 0.12 0.08 12.00 8.00
    9561 50 4 2 0 0 0 0 1 7 0.14 0.10 12.00 8.00
    9563 50 4 6 0 0 0 0 2 12 0.24 0.12 18.00 14.00
    9567 50 8 5 0 0 0 0 2 15 0.30 0.20 22.00 16.00
    9572 50 6 5 0 0 0 0 4 15 0.30 0.20 24.00 18.00
    9575 50 5 4 0 0 0 0 2 11 0.22 0.14 16.00 10.00
    9581 50 8 4 0 0 0 0 2 14 0.28 0.20 22.00 18.00
Average         6.1 3.9 0.0 0.0 0.0 0.0 1.8 11.8 0.24 0.16 18.50 13.50
± SEM                         0.03 0.02 1.68 1.50
 
Test Chemical L-Ascorbic acid 
500         
 9544 50 1 1 0 0 0 0 4 6 0.12 0.10 6.00 6.00
    9551 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9565 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9566 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9574 50 0 1 1 1 0 0 0 3 0.06 0.02 6.00 2.00
    9582 50 0 0 0 0 0 0 2 2 0.04 0.04 2.00 2.00
    9584 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9587 50 2 0 0 0 0 0 1 3 0.06 0.06 4.00 4.00
Average         0.6 0.8 0.1 0.1 0.0 0.0 0.9 2.5 0.05 0.03 3.75 2.25
± SEM                         0.01 0.01 0.96 0.70
 
Test Chemical L-Ascorbic acid 
1000         
 9547 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    9550 50 4 4 0 0 0 0 0 8 0.16 0.08 14.00 8.00
    9553 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9554 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9557 50 1 1 0 0 0 0 1 3 0.06 0.04 6.00 4.00
    9560 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9568 50 1 3 0 0 0 0 1 5 0.10 0.04 10.00 4.00
    9571 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
Average         0.9 1.8 0.0 0.0 0.0 0.0 0.3 2.9 0.06 0.02 5.25 2.25
± SEM                         0.02 0.01 1.73 1.03
 
Test Chemical L-Ascorbic acid 
2000         
 9540 50 5 4 0 0 0 0 0 9 0.18 0.10 16.00 10.00
    9541 50 4 4 0 0 0 0 0 8 0.16 0.08 14.00 8.00
    9543 50 0 2 0 0 0 0 2 4 0.08 0.04 4.00 0.00
    9548 50 1 4 0 0 0 0 0 5 0.10 0.02 6.00 2.00
    9562 50 4 1 0 0 0 0 1 6 0.12 0.10 12.00 10.00
    9564 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9569 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9585 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.8 2.1 0.0 0.0 0.0 0.0 0.4 4.3 0.09 0.04 7.00 3.75
± SEM                         0.02 0.02 2.20 1.67
 
Vehicle Control No Stressor 
 0         
 9539 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9545 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    9549 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9552 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9556 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9570 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9576 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9583 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
Average         0.4 0.8 0.0 0.0 0.0 0.0 0.3 1.4 0.03 0.01 2.25 0.75
± SEM                         0.01 0.01 0.70 0.37
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation