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Study Information
Study Attribute Value
CEBS Accession Number: 002-02340-0017-0000-9
Chemical Name: L-Ascorbic acid
CASRN: 50-81-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 592095_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
09/14/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 10009 50 7 8 0 0 0 0 2 17 0.34 0.18 26.00 16.00
    10017 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10023 50 7 7 0 0 0 0 0 14 0.28 0.14 22.00 14.00
    10026 50 7 1 0 0 0 1 4 13 0.26 0.24 22.00 20.00
    10041 50 7 2 0 0 0 0 1 10 0.20 0.16 18.00 16.00
    10046 50 6 1 0 0 0 0 1 8 0.16 0.14 12.00 12.00
    10060 50 2 1 0 0 0 0 2 5 0.10 0.08 12.00 10.00
    10065 50 6 8 2 0 0 0 1 17 0.34 0.18 24.00 14.00
Average         5.5 3.6 0.3 0.0 0.0 0.1 1.4 10.9 0.22 0.15 17.75 13.25
± SEM                         0.04 0.02 2.49 1.69
 
Test Chemical L-Ascorbic acid 
500         
 10042 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    10044 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10049 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10066 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    10067 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10071 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10073 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    10076 50 1 0 0 0 0 0 1 2 0.04 0.04 4.00 4.00
Average         0.5 1.4 0.0 0.0 0.0 0.0 0.3 2.1 0.04 0.02 4.00 1.25
± SEM                         0.01 0.01 1.00 0.53
 
Test Chemical L-Ascorbic acid 
1000         
 10045 50 1 1 1 0 0 0 0 3 0.06 0.04 6.00 4.00
    10052 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10054 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    10057 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10062 50 0 0 0 0 1 0 0 1 0.02 0.02 2.00 2.00
    10064 50 2 1 0 0 0 0 0 3 0.06 0.04 8.00 6.00
Average         0.7 1.2 0.2 0.0 0.2 0.0 0.0 2.2 0.04 0.02 4.67 2.33
± SEM                         0.01 0.01 0.99 0.95
 
Test Chemical L-Ascorbic acid 
2000         
 10043 50 2 1 0 0 0 0 1 4 0.08 0.06 6.00 4.00
    10048 50 3 5 0 0 0 0 0 8 0.16 0.06 12.00 4.00
    10058 50 4 5 0 0 0 0 0 9 0.18 0.08 14.00 6.00
    10061 4 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10068 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    10070 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10075 50 3 3 0 0 0 0 0 6 0.12 0.06 12.00 6.00
    10077 50 4 0 1 0 0 0 2 7 0.14 0.14 8.00 8.00
Average         2.0 2.5 0.1 0.0 0.0 0.0 0.4 5.0 0.10 0.05 9.14 4.00
± SEM                         0.02 0.02 1.28 1.08
 
Vehicle Control No Stressor 
 0         
 10022 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10031 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10038 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10056 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10059 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10063 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10069 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    10074 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 2.00
Average         0.6 0.9 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.01 2.50 1.00
± SEM                         0.01 0.01 0.91 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation