| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02340-0016-0000-8 |
| Chemical Name: | L-Ascorbic acid |
| CASRN: | 50-81-7 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 592095_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 06/01/1988 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
8700 | 25 | 5.46 | ± | 0.436 |
| 8712 | 25 | 6.18 | ± | 0.561 | |||
| 8714 | 25 | 5.96 | ± | 0.508 | |||
| 8722 | 25 | 5.35 | ± | 0.461 | |||
| Average | 5.74 | ± | 0.197 | ||||
| Test Chemical | L-Ascorbic acid |
550 |
8724 | 25 | 6.53 | ± | 0.533 |
| 8725 | 25 | 7.17 | ± | 0.605 | |||
| 8731 | 25 | 7.91 | ± | 0.551 | |||
| 8734 | 25 | 6.65 | ± | 0.405 | |||
| Average | 7.07 | ± | 0.314 | ||||
| Test Chemical | L-Ascorbic acid |
1100 |
8726 | 25 | 9.11 | ± | 0.815 |
| 8732 | 25 | 6.46 | ± | 0.598 | |||
| 8733 | 25 | 8.72 | ± | 0.622 | |||
| 8738 | 25 | 7.42 | ± | 0.616 | |||
| Average | 7.93 | ± | 0.606 | ||||
| Test Chemical | L-Ascorbic acid |
2200 |
8723 | 25 | 7.21 | ± | 0.485 |
| 8729 | 25 | 8.98 | ± | 0.689 | |||
| 8730 | 25 | 7.55 | ± | 0.627 | |||
| 8739 | 25 | 7.56 | ± | 0.724 | |||
| Average | 7.82 | ± | 0.393 | ||||
| Positive Control | Mitomycin-C |
0.5 |
8702 | 25 | 6.98 | ± | 0.560 |
| 8706 | 25 | 12.43 | ± | 0.703 | |||
| 8721 | 25 | 13.51 | ± | 0.887 | |||
| 8728 | 25 | 9.14 | ± | 0.499 | |||
| Average | 10.54 | ± | 1.502 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed