| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02340-0016-0000-8 |
| Chemical Name: | L-Ascorbic acid |
| CASRN: | 50-81-7 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 592095_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 07/20/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
9176 | 25 | 5.18 | ± | 0.366 |
| 9185 | 25 | 4.92 | ± | 0.513 | |||
| 9198 | 25 | 5.79 | ± | 0.520 | |||
| 9218 | 25 | 4.93 | ± | 0.405 | |||
| Average | 5.20 | ± | 0.204 | ||||
| Test Chemical | L-Ascorbic acid |
500 |
9203 | 25 | 5.41 | ± | 0.450 |
| 9210 | 25 | 5.06 | ± | 0.427 | |||
| 9212 | 25 | 4.97 | ± | 0.396 | |||
| 9220 | 25 | 6.20 | ± | 0.513 | |||
| Average | 5.41 | ± | 0.280 | ||||
| Test Chemical | L-Ascorbic acid |
1000 |
9197 | 25 | 6.59 | ± | 0.499 |
| 9200 | 25 | 5.34 | ± | 0.422 | |||
| 9215 | 25 | 6.55 | ± | 0.470 | |||
| 9219 | 25 | 6.40 | ± | 0.493 | |||
| Average | 6.22 | ± | 0.295 | ||||
| Test Chemical | L-Ascorbic acid |
2000 |
9196 | 25 | 6.04 | ± | 0.565 |
| 9207 | 25 | 5.91 | ± | 0.526 | |||
| 9214 | 25 | 5.96 | ± | 0.618 | |||
| 9217 | 25 | 6.44 | ± | 0.624 | |||
| Average | 6.09 | ± | 0.120 | ||||
| Positive Control | Mitomycin-C |
0.5 |
9172 | 25 | 10.86 | ± | 0.843 |
| 9181 | 25 | 10.99 | ± | 0.725 | |||
| 9202 | 25 | 8.91 | ± | 0.581 | |||
| 9206 | 25 | 11.33 | ± | 0.771 | |||
| Average | 10.53 | ± | 0.545 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed