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Study Information
Study Attribute Value
CEBS Accession Number: 002-02380-0022-0000-9
Chemical Name: Malaoxon
CASRN: 1634-78-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 635239_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/13/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 9842 50 5 1 1 0 0 0 0 7 0.14 0.12 14.00 12.00
    9843 50 2 4 0 0 0 0 0 6 0.12 0.04 14.00 6.00
    9844 50 6 1 0 0 0 0 1 8 0.16 0.14 12.00 12.00
    9845 50 11 2 1 0 0 0 1 15 0.30 0.26 26.00 22.00
    9846 50 12 7 0 0 0 0 1 20 0.40 0.26 22.00 20.00
    9847 50 6 3 0 0 0 0 0 9 0.18 0.12 18.00 12.00
    9848 50 5 1 0 0 0 0 0 6 0.12 0.10 10.00 8.00
    9849 50 2 3 2 0 0 0 0 7 0.14 0.08 10.00 8.00
Average         6.1 2.8 0.5 0.0 0.0 0.0 0.4 9.8 0.20 0.14 15.75 12.50
± SEM                         0.04 0.03 2.05 2.03
 
Test Chemical Malaoxon 
7.5       
 9772 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9773 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9774 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    9776 50 4 0 1 0 0 0 0 5 0.10 0.10 10.00 10.00
    9778 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9779 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    9780 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
    9781 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
Average         2.1 0.1 0.1 0.0 0.0 0.0 0.0 2.4 0.05 0.05 4.00 3.75
± SEM                         0.01 0.01 1.13 1.10
 
Test Chemical Malaoxon 
15         
 9782 50 4 1 0 0 0 0 0 5 0.10 0.08 6.00 4.00
    9783 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9784 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9785 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    9787 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9788 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9789 50 1 0 1 0 0 0 0 2 0.04 0.04 2.00 2.00
    9791 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.3 0.3 0.1 0.0 0.0 0.0 0.0 1.6 0.03 0.03 2.25 2.00
± SEM                         0.01 0.01 0.59 0.38
 
Test Chemical Malaoxon 
30         
 9792 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9793 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9794 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    9795 50 4 4 2 0 0 0 0 10 0.20 0.12 14.00 8.00
    9796 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    9797 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9798 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    9799 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.3 1.4 0.3 0.0 0.0 0.0 0.0 2.9 0.06 0.03 4.25 2.25
± SEM                         0.02 0.01 1.44 0.96
 
Vehicle Control No Stressor 
 0         
 9832 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9833 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9834 50 2 1 1 0 0 0 0 4 0.08 0.06 8.00 6.00
    9835 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9836 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9837 50 4 3 0 0 0 0 0 7 0.14 0.08 14.00 8.00
    9838 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9839 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         1.1 0.8 0.1 0.0 0.0 0.0 0.0 2.0 0.04 0.03 4.00 2.50
± SEM                         0.02 0.01 1.77 1.12
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation