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Study Information
Study Attribute Value
CEBS Accession Number: 002-02380-0022-0000-9
Chemical Name: Malaoxon
CASRN: 1634-78-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 635239_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
10/01/1991 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 12405 50 35 10 4 0 0 0 0 49 0.98 0.78 42.00 34.00
    12406 50 21 2 0 0 0 0 0 23 0.46 0.42 22.00 22.00
    12407 50 23 2 1 0 0 0 0 26 0.52 0.48 32.00 30.00
    12409 50 51 2 0 0 0 0 1 54 1.08 1.04 42.00 42.00
    12410 50 22 1 1 0 0 0 1 25 0.50 0.48 24.00 24.00
    12411 50 5 2 1 0 0 0 0 8 0.16 0.12 12.00 8.00
    12412 50 9 3 0 0 0 0 0 12 0.24 0.18 14.00 12.00
    12413 50 21 2 0 0 0 0 1 24 0.48 0.44 30.00 28.00
Average         23.4 3.0 0.9 0.0 0.0 0.0 0.4 27.6 0.55 0.49 27.25 25.00
± SEM                         0.11 0.11 4.03 3.95
 
Test Chemical Malaoxon 
5         
 12335 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12336 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12337 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12338 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12339 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    12340 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    12341 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12342 50 3 3 0 0 0 0 0 6 0.12 0.06 8.00 4.00
Average         1.5 1.0 0.0 0.0 0.0 0.0 0.0 2.5 0.05 0.03 4.50 2.75
± SEM                         0.02 0.01 1.24 0.65
 
Test Chemical Malaoxon 
10         
 12345 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    12346 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12347 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12348 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12350 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12351 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    12352 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    12353 50 5 1 0 0 0 0 0 6 0.12 0.10 10.00 8.00
Average         1.9 0.8 0.0 0.0 0.0 0.0 0.0 2.6 0.05 0.04 4.75 3.50
± SEM                         0.01 0.01 1.19 1.12
 
Test Chemical Malaoxon 
20         
 12355 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12356 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12357 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12358 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12359 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    12361 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    12362 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12363 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.4 0.8 0.0 0.0 0.0 0.0 0.0 2.1 0.04 0.03 4.25 2.75
± SEM                         0.01 0.01 0.70 0.65
 
Vehicle Control No Stressor 
 0         
 12395 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12396 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12397 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12398 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    12399 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12400 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12401 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    12402 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.3 0.6 0.0 0.0 0.0 0.0 0.0 1.9 0.04 0.03 3.75 2.50
± SEM                         0.01 0.01 0.70 0.73
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation